{"id":"W2150714767","doi":"10.1242/jcs.138982","title":"Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release; both impinge on GLUT4 translocation","year":2014,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; Insulin; Ryanodine receptor; GLUT4; Insulin receptor; Phosphatidylinositol; Internal medicine; Chromosomal translocation; Endocrinology; Inositol; Glucose uptake; Cell biology; Receptor; Kinase; Biochemistry; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005928503,0.00006720713,0.00007399746,0.00008614358,0.0001106296,0.00004181273,0.0001151704,0.00005466007,0.000006226427],"category_scores_gemma":[0.00007390949,0.00005422378,0.00002593459,0.0001267901,0.00007924839,0.00002627552,0.00001191082,0.00007474899,0.000001549275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002074766,"about_ca_system_score_gemma":0.00008864728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005661371,"about_ca_topic_score_gemma":0.000004710845,"domain_scores_codex":[0.999263,0.00004375769,0.0001757759,0.0001539282,0.0002490719,0.0001145035],"domain_scores_gemma":[0.9994369,0.000006842179,0.0001651443,0.0001043301,0.0001610305,0.0001257679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001143028,0.00005138302,0.00005472152,0.000003443132,0.000001739439,4.228266e-7,0.00008879294,0.0009482684,0.9880141,0.0000370057,0.00005202476,0.01063378],"study_design_scores_gemma":[0.0006252433,0.0009513217,0.004267484,0.0000160613,0.000004435392,0.00002591065,0.00006492565,0.003959637,0.9869348,0.00005726649,0.0030115,0.00008136818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900665,0.00008071525,0.008780546,0.0001758481,0.0002690224,0.00004747168,7.874287e-7,0.000003276966,0.0005758125],"genre_scores_gemma":[0.9989738,0.0001433671,0.0002380591,0.0002138671,0.0002974656,6.370707e-7,0.000002606618,0.00000518564,0.0001249916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01055241,"threshold_uncertainty_score":0.2211181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092903397191044,"score_gpt":0.2539439046713288,"score_spread":0.2430148706994184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}