{"id":"W2150714767","doi":"10.1242/jcs.138982","title":"Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release; both impinge on GLUT4 translocation","year":2014,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; Insulin; Ryanodine receptor; GLUT4; Insulin receptor; Phosphatidylinositol; Internal medicine; Chromosomal translocation; Endocrinology; Inositol; Glucose uptake; Cell biology; Receptor; Kinase; Biochemistry; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034958,0.0006371824,0.0003803739,0.0002364909,0.0001636592,0.0003060574,0.0001695743,0.0005426544,0.002030998],"category_scores_gemma":[0.0001050948,0.0001733055,0.000711666,0.0002653229,0.0002690951,0.0003599507,0.0003521803,0.000750374,0.0003131498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615719,"about_ca_system_score_gemma":0.000132083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002201709,"about_ca_topic_score_gemma":0.00035881,"domain_scores_codex":[0.9997568,0.0000269126,0.00002858952,0.00006886702,0.00005889609,0.00005999029],"domain_scores_gemma":[0.9998722,0.00001627169,0.00003697833,0.00002114496,0.00001471775,0.00003873135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006589948,0.00005852505,0.0001962908,0.00006460358,0.00001126387,0.00009146598,0.00001577461,0.00002291572,0.997786,0.00005196229,0.00004431965,0.0009978405],"study_design_scores_gemma":[0.0001005622,0.0008262543,0.01152314,0.000009271492,0.0000347642,0.0002501266,0.00005600903,0.0004136305,0.9840267,0.00008823659,0.00266274,0.000008623554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871622,0.002556629,0.005273764,0.0002933387,0.0001786916,0.0001081017,0.000967698,0.0001067397,0.003352964],"genre_scores_gemma":[0.9891089,0.001349638,0.002815417,0.0002791838,0.00005364219,0.0001452722,0.0008472439,0.00003418131,0.005366489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002030998,"threshold_uncertainty_score":0.006794393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092903397191044,"score_gpt":0.2539439046713288,"score_spread":0.2430148706994184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}