{"id":"W2150764932","doi":"10.1038/cgt.2013.10","title":"Sustained production of a soluble IGF-I receptor by gutless adenovirus-transduced host cells protects from tumor growth in the liver","year":2013,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; National Research Council Canada; Biotechnology Research Institute; McGill University; Montreal Neurological Institute and Hospital; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Genetic enhancement; Stromal cell; Cancer research; In vivo; Gene delivery; Biology; Metastasis; In vitro; Cancer cell; Receptor; Virus; HEK 293 cells; Adenoviridae; Cancer; Molecular biology; Virology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003447116,0.0002370866,0.0002263523,0.00006301297,0.00008198975,0.00003748388,0.0005490296,0.0001233882,0.0004514825],"category_scores_gemma":[0.00002053674,0.0001813607,0.00009079854,0.000281,0.0001553846,0.00001476211,0.00004660883,0.0001883703,0.00002248896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006105701,"about_ca_system_score_gemma":0.0002857372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002028831,"about_ca_topic_score_gemma":0.0003775499,"domain_scores_codex":[0.9982007,0.0002967028,0.0002740192,0.0005155702,0.0002980458,0.0004149792],"domain_scores_gemma":[0.9989827,0.0000193784,0.000123678,0.0005438436,0.0002616007,0.00006885899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00210768,0.0001757766,0.0001365061,0.00002562335,0.00008166012,0.000001231715,0.0006473116,0.00002157085,0.9827288,0.000001265165,0.008837578,0.005234939],"study_design_scores_gemma":[0.001328831,0.001203945,0.0004124776,0.00001771043,0.000005373909,9.771542e-7,0.0002562453,0.00001607048,0.9940107,0.00005848657,0.002466912,0.0002222025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857489,0.0110174,0.00004360009,0.0010169,0.0002130127,0.001842986,0.00006333032,0.00001296623,0.00004090007],"genre_scores_gemma":[0.9899331,0.007343763,0.0001016784,0.000577167,0.0004246088,0.001052546,0.00008908151,0.00005485117,0.000423182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01128191,"threshold_uncertainty_score":0.7395676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152660956230375,"score_gpt":0.2624725811275112,"score_spread":0.2472064855044737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}