{"id":"W2150764932","doi":"10.1038/cgt.2013.10","title":"Sustained production of a soluble IGF-I receptor by gutless adenovirus-transduced host cells protects from tumor growth in the liver","year":2013,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; National Research Council Canada; Biotechnology Research Institute; McGill University; Montreal Neurological Institute and Hospital; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Genetic enhancement; Stromal cell; Cancer research; In vivo; Gene delivery; Biology; Metastasis; In vitro; Cancer cell; Receptor; Virus; HEK 293 cells; Adenoviridae; Cancer; Molecular biology; Virology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852561,0.0003580123,0.0002873621,0.0002177804,0.0001314925,0.0004064731,0.0001669512,0.0002405734,0.001046165],"category_scores_gemma":[0.0001032362,0.0001804184,0.0002520927,0.0001151561,0.0002928394,0.0002651893,0.0001410648,0.0006559788,0.0003770965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003927162,"about_ca_system_score_gemma":0.0002920977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008470761,"about_ca_topic_score_gemma":0.0008998527,"domain_scores_codex":[0.9998978,0.00001486122,0.00001034644,0.00001888996,0.00002229416,0.00003570301],"domain_scores_gemma":[0.9998471,0.00003477567,0.00003498617,0.00002864074,0.00001446677,0.00004002052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001629364,0.00001578244,0.00008843414,0.00001379859,0.000003198683,0.00001830121,0.00001020515,0.00006292084,0.9989654,0.0001054655,0.00002221813,0.0005314083],"study_design_scores_gemma":[0.00002917874,0.0004261731,0.0006735781,0.000002696368,0.00001226293,0.00007865468,0.00001894237,0.000661313,0.9972287,0.00002453495,0.000840776,0.000003276066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953697,0.0009805537,0.002570959,0.00008675667,0.00005375287,0.00001510623,0.0002257437,0.00008457063,0.0006127632],"genre_scores_gemma":[0.9958333,0.0003264105,0.001520126,0.00002138574,0.0000112083,0.00001177148,0.0002774623,0.00001975502,0.001978739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046165,"threshold_uncertainty_score":0.003499746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152660956230375,"score_gpt":0.2624725811275112,"score_spread":0.2472064855044737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}