{"id":"W2150801177","doi":"10.1073/pnas.0702756104","title":"Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sheridan College; William Osler Health System","funders":"Medical Research and Materiel Command; McGill University; University of Nebraska Medical Center","keywords":"Butyrylcholinesterase; Transgene; Recombinant DNA; Organophosphate; Nerve agent; Genetically modified mouse; Genetically modified organism; Pharmacology; Chemistry; Biochemistry; Biology; Enzyme; Pesticide; Aché; Acetylcholinesterase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003518751,0.0003456581,0.0002225816,0.0003212962,0.0001183204,0.0002935071,0.0002779083,0.0005229217,0.001265337],"category_scores_gemma":[0.0002972344,0.0002398021,0.0002730606,0.0001467385,0.0002763528,0.0002176498,0.0001768306,0.00103262,0.0005650697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003670517,"about_ca_system_score_gemma":0.0002218204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004736831,"about_ca_topic_score_gemma":0.0005147696,"domain_scores_codex":[0.9998288,0.00003287402,0.00002075204,0.0000346388,0.00004355266,0.00003945288],"domain_scores_gemma":[0.9997613,0.00007065905,0.0000667983,0.00003210696,0.00002608821,0.0000430837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008778456,0.00002825003,0.00008321276,0.00001435671,0.000006822759,0.00004179311,0.00001357648,0.00003631055,0.9991763,0.00007950385,0.00003661255,0.0003954125],"study_design_scores_gemma":[0.0000583259,0.0002710422,0.001306174,0.000009140515,0.00003257648,0.0003619205,0.0000199944,0.0008042625,0.9923853,0.00007762993,0.004668919,0.000004830034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828818,0.001864645,0.01143963,0.0005775917,0.0001178996,0.0001520926,0.001113042,0.0001796537,0.001673716],"genre_scores_gemma":[0.9775524,0.001351654,0.008340506,0.0002375992,0.0000420752,0.0001281568,0.003336508,0.0001521427,0.008859028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265337,"threshold_uncertainty_score":0.004233003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03018768348773006,"score_gpt":0.3096176397650391,"score_spread":0.2794299562773091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}