{"id":"W2150801177","doi":"10.1073/pnas.0702756104","title":"Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sheridan College; William Osler Health System","funders":"Medical Research and Materiel Command; McGill University; University of Nebraska Medical Center","keywords":"Butyrylcholinesterase; Transgene; Recombinant DNA; Organophosphate; Nerve agent; Genetically modified mouse; Genetically modified organism; Pharmacology; Chemistry; Biochemistry; Biology; Enzyme; Pesticide; Aché; Acetylcholinesterase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001003764,0.00008610117,0.0001243238,0.0000762538,0.0001168031,0.000008423317,0.0004103198,0.00008663472,0.000003346383],"category_scores_gemma":[0.0002135271,0.00006083765,0.00007134894,0.0003521024,0.0002490634,0.000009667912,0.00008768251,0.00007051633,3.677366e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008976024,"about_ca_system_score_gemma":0.00002056714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000103769,"about_ca_topic_score_gemma":4.332132e-7,"domain_scores_codex":[0.9988096,0.000004233358,0.0003491429,0.0002903444,0.0004132042,0.0001335262],"domain_scores_gemma":[0.9992814,0.000009569841,0.0003783727,0.00001415686,0.0002799755,0.0000364979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005273565,0.0000349821,0.004768998,0.00002172568,0.0000138402,4.13323e-9,0.00007956869,0.00005722633,0.9942092,0.0003374311,0.00005217076,0.0003720828],"study_design_scores_gemma":[0.000143427,0.0001585282,0.08641465,0.0000521343,0.000007489751,0.000001310797,0.00008489209,0.00001111583,0.9115025,0.001240389,0.0003141871,0.00006937633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985908,0.0002706773,0.00001130545,0.0004764678,0.00002598115,0.0002243465,0.00001126715,0.000002784346,0.0003864231],"genre_scores_gemma":[0.9982623,0.00003862311,0.001358695,0.0001198806,0.0001120641,0.000004124453,5.308345e-7,0.000005705997,0.00009808903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08270673,"threshold_uncertainty_score":0.2480887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03018768348773006,"score_gpt":0.3096176397650391,"score_spread":0.2794299562773091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}