{"id":"W2150816534","doi":"10.1128/jvi.74.17.7869-7877.2000","title":"Induction of p53-Independent Apoptosis by the Adenovirus E4orf4 Protein Requires Binding to the Bα Subunit of Protein Phosphatase 2A","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Biology; Protein phosphatase 2; Mutant; Protein subunit; Transfection; Molecular biology; Programmed cell death; Apoptosis; Phosphatase; Point mutation; Cell; Mutation; Adenoviridae; Cell culture; Cell biology; Gene; Genetics; Phosphorylation; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001364862,0.0001552786,0.0002690665,0.0001086322,0.0001100532,0.00001475596,0.0006825043,0.0001932055,0.0003135814],"category_scores_gemma":[0.0001284631,0.00009537686,0.0001488813,0.0002167442,0.0002245642,0.00001164706,0.00009075904,0.0003702883,0.00001414616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003094268,"about_ca_system_score_gemma":0.0001682677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008440703,"about_ca_topic_score_gemma":0.00006706573,"domain_scores_codex":[0.9980183,0.000481413,0.0005896816,0.0001938168,0.0004163201,0.0003004263],"domain_scores_gemma":[0.9987957,0.00002795839,0.0004515997,0.0004482455,0.000183737,0.00009276656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00524771,0.0001579229,0.00008590736,0.00001225071,0.0001611202,0.000002890696,0.0001099744,0.000248388,0.9735259,0.00001790254,0.001354731,0.0190753],"study_design_scores_gemma":[0.0007714945,0.006316181,0.0001684025,0.00002704875,0.0000282589,0.00005048523,0.0001149156,0.000007480161,0.9787942,0.00005816726,0.01357356,0.00008980245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994433,0.002029939,0.00007660135,0.002689346,0.00007236568,0.000577642,0.00005074706,0.000002177244,0.00006813815],"genre_scores_gemma":[0.998592,0.0002676674,0.00008413086,0.0002294538,0.0002264093,0.00003897775,0.00001141539,0.0000228798,0.0005270561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0189855,"threshold_uncertainty_score":0.3889356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01752753388622321,"score_gpt":0.2877571555202533,"score_spread":0.2702296216340301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}