{"id":"W2150816534","doi":"10.1128/jvi.74.17.7869-7877.2000","title":"Induction of p53-Independent Apoptosis by the Adenovirus E4orf4 Protein Requires Binding to the Bα Subunit of Protein Phosphatase 2A","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Biology; Protein phosphatase 2; Mutant; Protein subunit; Transfection; Molecular biology; Programmed cell death; Apoptosis; Phosphatase; Point mutation; Cell; Mutation; Adenoviridae; Cell culture; Cell biology; Gene; Genetics; Phosphorylation; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667745,0.0004010086,0.0002301551,0.0002026035,0.0001714811,0.0002715005,0.0001559644,0.0002335773,0.001157993],"category_scores_gemma":[0.0002417029,0.0001778223,0.0004474238,0.0001515197,0.0002929086,0.0001934705,0.0002449719,0.0004665473,0.0004184074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00039586,"about_ca_system_score_gemma":0.0002221538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006306469,"about_ca_topic_score_gemma":0.0005501896,"domain_scores_codex":[0.9997974,0.0000418461,0.00002619643,0.00003561237,0.00004771542,0.00005126314],"domain_scores_gemma":[0.9998379,0.00004695553,0.00004115443,0.00003390415,0.0000166042,0.00002354019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056518,0.00002320116,0.000328259,0.00001462456,0.00000467481,0.00004011887,0.000006497112,0.00005016341,0.9986717,0.00007053319,0.00001231443,0.0006724842],"study_design_scores_gemma":[0.00001604064,0.0001911358,0.006690544,0.000004204641,0.000008401911,0.0002564235,0.00001846853,0.0008264784,0.9906422,0.00005313971,0.001289317,0.000003509449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961413,0.0005235095,0.002476839,0.00003223355,0.00001378603,0.00002103326,0.0001648737,0.00002763441,0.0005988523],"genre_scores_gemma":[0.9943251,0.0003748173,0.002640776,0.0000212055,0.000004590556,0.00002944819,0.0008093212,0.00001248752,0.001782083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157993,"threshold_uncertainty_score":0.003873885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01752753388622321,"score_gpt":0.2877571555202533,"score_spread":0.2702296216340301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}