{"id":"W2150824599","doi":"10.1161/01.atv.0000245791.53245.ee","title":"NPC1L1: Evolution From Pharmacological Target to Physiological Sterol Transporter","year":2006,"lang":"en","type":"review","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Schwartz/Reisman Emergency Medicine Institute; Robarts Clinical Trials","funders":"Ontario Genomics; Ontario Genomics Institute; Genome Canada; Heart and Stroke Foundation of Canada","keywords":"Ezetimibe; Transporter; Biology; Sterol; Phenotype; Drug discovery; Cholesterol; Function (biology); Computational biology; Bioinformatics; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004228211,0.0006291884,0.001026817,0.001462579,0.0002790122,0.0008470995,0.0006987316,0.001046127,0.002897778],"category_scores_gemma":[0.0003857595,0.0002068329,0.0002032847,0.001657155,0.0005079655,0.001313953,0.0004682326,0.001248019,0.003577966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000738828,"about_ca_system_score_gemma":0.0007130094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008851629,"about_ca_topic_score_gemma":0.001251044,"domain_scores_codex":[0.999909,0.00001491323,0.00001121018,0.00002226855,0.00003426377,0.000008322063],"domain_scores_gemma":[0.9998782,0.00003349018,0.00001798916,0.00000574511,0.00004305576,0.0000215111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001190408,0.00004996249,0.000241412,0.005137851,0.00004623923,0.0004646642,0.00006776267,0.0004182524,0.005454432,0.005330065,0.02170236,0.960968],"study_design_scores_gemma":[0.00002133192,0.00006032398,0.0006501472,0.0006022402,0.0000370744,0.001824427,0.00004386345,0.00008276026,0.001117679,0.001708906,0.9938378,0.00001339424],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000356838,0.9966497,0.0004323111,0.0005905189,0.0001954019,0.000005576891,0.00001973126,0.00001796747,0.001731875],"genre_scores_gemma":[0.001704656,0.9949066,0.000724317,0.0003816387,0.0001564008,0.00000994185,0.00004158548,0.000003869417,0.002071015],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002897778,"threshold_uncertainty_score":0.00969398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09317212008508108,"score_gpt":0.3597087448729039,"score_spread":0.2665366247878229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}