{"id":"W2150853463","doi":"10.1242/bio.20134267","title":"Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain","year":2013,"lang":"en","type":"article","venue":"Biology Open","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"Canadian Institutes of Health Research","keywords":"PDZ domain; Biology; Synaptic vesicle; Scaffold protein; Synaptosome; Cell biology; Active zone; Fusion protein; Biophysics; Vesicle; Biochemistry; Membrane; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248809,0.000112085,0.0001517524,0.00002145134,0.00007342615,0.0000217439,0.0004870697,0.0001590567,0.00008483147],"category_scores_gemma":[0.00001205262,0.00007593574,0.00006881914,0.00003907094,0.0001780569,0.000005952093,0.0002014976,0.00005868668,0.00002172199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004221143,"about_ca_system_score_gemma":0.00002911208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003836043,"about_ca_topic_score_gemma":0.0001104809,"domain_scores_codex":[0.9992792,0.00006684888,0.000200097,0.0002374792,0.00003396075,0.0001824239],"domain_scores_gemma":[0.9995112,0.00001187222,0.00008444183,0.0003038026,0.0000479521,0.00004068086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005236611,0.00002778335,0.00398842,0.000008610979,0.00005309867,0.000001727926,0.00008821503,0.000001906675,0.9939854,0.0001351135,0.0002136845,0.001443718],"study_design_scores_gemma":[0.002147104,0.001712042,0.0291256,0.00008226414,0.0001009422,0.0001792988,0.0006102909,0.0003984293,0.8697759,0.006031708,0.08915468,0.0006817143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883394,0.0003789317,0.009111081,0.0002820189,0.0001378679,0.0004504982,0.000008634493,0.000004397924,0.001287234],"genre_scores_gemma":[0.9984266,0.00004773397,0.0002272896,0.0001375577,0.0001006298,0.00005454695,0.00043015,0.00001086065,0.0005646501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1242094,"threshold_uncertainty_score":0.309657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241034896364755,"score_gpt":0.2484414255638407,"score_spread":0.2360310766001932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}