{"id":"W2150856909","doi":"10.1371/journal.pgen.1001372","title":"Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Medical Research Council; Versus Arthritis; Servier; Erasmus Medisch Centrum; Healthway; Australian Cancer Research Foundation; National Institute for Health and Care Research; National Health and Medical Research Council; Chronic Disease Research Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Sanofi; European Commission; ZonMw; Amgen; Pfizer; Health Research Council of New Zealand; Geelong Region Medical Research Foundation; Eli Lilly and Company","keywords":"Genome-wide association study; Bone mineral; Biology; Genetic association; Osteoporosis; Genetics; Bone density; Population; Gene; Internal medicine; Candidate gene; Single-nucleotide polymorphism; Endocrinology; Medicine; Genotype; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00178963,0.0003953997,0.0005774183,0.0006640764,0.0003879011,0.0004503216,0.0003254492,0.0004499824,0.0009423552],"category_scores_gemma":[0.001856872,0.0001686209,0.0008923631,0.000926994,0.0004189556,0.0001161705,0.0004780169,0.0004573972,0.0001270234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316546,"about_ca_system_score_gemma":0.0003168478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018529,"about_ca_topic_score_gemma":0.002167492,"domain_scores_codex":[0.9987184,0.0005680594,0.00009843153,0.0003454832,0.0001789102,0.00009072583],"domain_scores_gemma":[0.9988839,0.0005037264,0.0002263632,0.0002089154,0.00006385714,0.0001133047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006494727,0.0004797127,0.6884911,0.0002060296,0.005006596,0.002393119,0.0004670732,0.00172492,0.2507316,0.000873541,0.0007141853,0.04241739],"study_design_scores_gemma":[0.0004674315,0.001284217,0.9748732,0.0000231292,0.002059716,0.002582597,0.0001096576,0.004780677,0.01072327,0.0007323286,0.002324621,0.00003910435],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942556,0.0002735471,0.00479144,0.00004744524,0.00001271283,0.00002903759,0.0002853526,0.00004434321,0.0002606695],"genre_scores_gemma":[0.9943612,0.0001453455,0.004536336,0.00007773384,0.00001681781,0.0000446396,0.0005778602,0.00002130196,0.0002188188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178963,"threshold_uncertainty_score":0.009464562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0863447815316636,"score_gpt":0.3084976867079034,"score_spread":0.2221529051762398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}