{"id":"W2150869840","doi":"10.1126/science.1233692","title":"Root Effect Hemoglobin May Have Evolved to Enhance General Tissue Oxygen Delivery","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Naturvidenskab og Teknologi, Aarhus Universitet; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; National Science Foundation; National Institutes of Health; Aarhus Universitet","keywords":"Hemoglobin; Oxygen; Carbonic anhydrase; Oxygenation; Carbon dioxide; Red Cell; Biophysics; Bohr effect; Biology; Perfusion; Chemistry; Biochemistry; Anatomy; Cell biology; Internal medicine; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620679,0.0001475594,0.0001127709,0.00005616117,0.0001652077,0.00008111584,0.0003816772,0.00008759822,0.0001154545],"category_scores_gemma":[0.0001105862,0.0001230952,0.00004019758,0.0002441388,0.0001660842,0.00001805183,0.0001839256,0.00006344501,0.0003549209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003831021,"about_ca_system_score_gemma":0.00009770347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001207719,"about_ca_topic_score_gemma":0.00004337599,"domain_scores_codex":[0.9986562,0.00003323477,0.000130578,0.0005432747,0.0002410985,0.0003956297],"domain_scores_gemma":[0.9991941,0.000007152526,0.00003607433,0.0004161723,0.0001458844,0.0002005917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001431482,0.000005894643,0.001919422,0.000004695472,0.000003627987,0.000001026082,0.00002173347,0.00005667531,0.9691243,0.000006200746,0.005477798,0.02336431],"study_design_scores_gemma":[0.00009786231,0.0003500758,0.02290345,0.000005440287,0.000004106639,0.00001027367,0.000009894924,0.0001014646,0.9385964,0.00003511611,0.03771619,0.000169732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940459,0.0001692453,0.002178763,0.0002197657,0.0004566198,0.0003452023,0.000004438004,0.00001810885,0.002561929],"genre_scores_gemma":[0.9929534,0.00000644325,0.00216831,0.0006730563,0.0003275411,0.0000458528,0.0000139264,0.00001025741,0.003801279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03223839,"threshold_uncertainty_score":0.5019677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00370339272251572,"score_gpt":0.2616262324228641,"score_spread":0.2579228397003484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}