{"id":"W2150869840","doi":"10.1126/science.1233692","title":"Root Effect Hemoglobin May Have Evolved to Enhance General Tissue Oxygen Delivery","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Naturvidenskab og Teknologi, Aarhus Universitet; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; National Science Foundation; National Institutes of Health; Aarhus Universitet","keywords":"Hemoglobin; Oxygen; Carbonic anhydrase; Oxygenation; Carbon dioxide; Red Cell; Biophysics; Bohr effect; Biology; Perfusion; Chemistry; Biochemistry; Anatomy; Cell biology; Internal medicine; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005363605,0.0004469272,0.0004138024,0.0002371871,0.0004078815,0.0007782954,0.000595491,0.001718518,0.008917767],"category_scores_gemma":[0.0008488848,0.0001693374,0.0003070137,0.0002430833,0.0010703,0.001147414,0.0006106488,0.001391217,0.00156849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001119959,"about_ca_system_score_gemma":0.0003642442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001485819,"about_ca_topic_score_gemma":0.001762662,"domain_scores_codex":[0.9997833,0.00003048585,0.000008491522,0.00009035251,0.00004454355,0.00004279812],"domain_scores_gemma":[0.9997215,0.00006433851,0.00005426943,0.00003768893,0.00008289965,0.00003928443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005991005,0.0002104401,0.021695,0.0006802665,0.0002027045,0.002757166,0.0009091207,0.002156627,0.6570193,0.1142968,0.01306263,0.1864109],"study_design_scores_gemma":[0.0003039583,0.001753968,0.1973508,0.0003344846,0.0004987973,0.01251988,0.00155457,0.01492949,0.2988523,0.08735825,0.3842824,0.000261211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7641884,0.0176991,0.08338311,0.03077845,0.002911801,0.0001198235,0.0008942659,0.002238215,0.09778681],"genre_scores_gemma":[0.8947636,0.0047258,0.02142361,0.00702184,0.0006613324,0.00003670768,0.0003163596,0.0003939217,0.07065675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008917767,"threshold_uncertainty_score":0.02983296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00370339272251572,"score_gpt":0.2616262324228641,"score_spread":0.2579228397003484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}