{"id":"W2150949230","doi":"10.1242/dmm.002634","title":"Involucrin–claudin-6 tail deletion mutant (CΔ206) transgenic mice: a model of delayed epidermal permeability barrier formation and repair","year":2010,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Involucrin; Claudin; Biology; Transgene; Genetically modified mouse; Epidermis (zoology); Cell biology; Mutant; Phenotype; Tight junction; Immunology; Genetics; Cellular differentiation; Anatomy; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003242171,0.0003030243,0.0003384161,0.0001274957,0.0003843142,0.00003287338,0.0001794911,0.0001383169,0.00005637438],"category_scores_gemma":[0.0002212651,0.0002740183,0.0002438273,0.0001904612,0.0002095422,0.0008054172,0.00009447431,0.0002978902,0.000004210118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003300188,"about_ca_system_score_gemma":0.0001153871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002156896,"about_ca_topic_score_gemma":0.00005678786,"domain_scores_codex":[0.9978071,0.0001028523,0.0005388317,0.0006732106,0.0004945589,0.0003834579],"domain_scores_gemma":[0.9987116,0.00007606503,0.0001746982,0.0004890285,0.000176665,0.000371955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004735913,0.00007751813,0.00002822135,0.0001297683,0.0000195302,0.000003268161,0.001427982,0.004230354,0.9330661,0.0597682,0.00005092283,0.000724525],"study_design_scores_gemma":[0.0005417441,0.00006197856,0.000100784,0.000009703861,0.0001241465,0.000009881011,0.0001239114,0.6652249,0.1508115,0.1827224,0.00003184737,0.0002372614],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6892256,0.00006092713,0.3093366,0.0001494333,0.0002754546,0.0003997504,0.0002954865,0.0001519236,0.0001047737],"genre_scores_gemma":[0.9963046,0.00007444009,0.002704285,0.0006588108,0.00005200925,0.0001096523,0.00001658776,0.00003076456,0.00004889799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7822546,"threshold_uncertainty_score":0.9999712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02963053497901029,"score_gpt":0.2430425192824121,"score_spread":0.2134119843034019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}