{"id":"W2150963367","doi":"10.1186/1756-8935-4-12","title":"H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing","year":2011,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Directorate for Biological Sciences; Deutsche Forschungsgemeinschaft; Michael Smith Health Research BC","keywords":"Heterochromatin protein 1; Biology; Chromodomain; Gene silencing; Heterochromatin; Derepression; Genetics; Histone; Endogenous retrovirus; DNA methylation; Polycomb-group proteins; Psychological repression; Gene; Repressor; Chromatin; Genome; RNA; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002843813,0.0002695963,0.000294205,0.00002276311,0.0005298975,0.00009006778,0.0004146857,0.0001655598,0.00152134],"category_scores_gemma":[0.0001377775,0.0001321749,0.0001705637,0.0002751442,0.00005941196,0.0000972475,0.0001428997,0.0001356827,0.0001793258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007194734,"about_ca_system_score_gemma":0.00002631993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003250564,"about_ca_topic_score_gemma":0.001638697,"domain_scores_codex":[0.9980612,0.00007155224,0.0004632681,0.0005098305,0.0003114649,0.0005826998],"domain_scores_gemma":[0.9991342,0.0001384913,0.000265309,0.0001641319,0.0001170261,0.0001807738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003235376,0.0002719762,0.01568341,0.00004993665,0.00004014252,0.000008512297,0.0008315842,0.00002613794,0.9713517,0.0006158165,0.0005151568,0.01057328],"study_design_scores_gemma":[0.0008817933,0.001644007,0.4158451,0.0002101104,0.0001154884,0.00002416172,0.001973279,0.0012022,0.5649974,0.005301587,0.006658159,0.001146698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945353,0.0001628629,0.0002751632,0.0002895313,0.0002817823,0.0009959342,0.0003706035,0.0001246385,0.002964205],"genre_scores_gemma":[0.989759,0.00002845448,0.00726706,0.0001025159,0.0004616042,0.0001816568,0.00009349445,0.000005931573,0.002100275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4063542,"threshold_uncertainty_score":0.9993914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0462069993200496,"score_gpt":0.2215842216391591,"score_spread":0.1753772223191095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}