{"id":"W2150963367","doi":"10.1186/1756-8935-4-12","title":"H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing","year":2011,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Directorate for Biological Sciences; Deutsche Forschungsgemeinschaft; Michael Smith Health Research BC","keywords":"Heterochromatin protein 1; Biology; Chromodomain; Gene silencing; Heterochromatin; Derepression; Genetics; Histone; Endogenous retrovirus; DNA methylation; Polycomb-group proteins; Psychological repression; Gene; Repressor; Chromatin; Genome; RNA; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223008,0.0004154863,0.0002615417,0.0002590654,0.0002474517,0.0006010681,0.0005920889,0.0004027804,0.003381454],"category_scores_gemma":[0.0001743447,0.0002691012,0.0003468764,0.0001603931,0.0003696992,0.0002774225,0.000382445,0.0007571934,0.001033622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010534,"about_ca_system_score_gemma":0.0002695583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000632775,"about_ca_topic_score_gemma":0.001054315,"domain_scores_codex":[0.9996957,0.00004174725,0.000036456,0.00006369461,0.0001086588,0.00005378253],"domain_scores_gemma":[0.9996868,0.00007456297,0.00007752937,0.00005953233,0.0000184187,0.0000830331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005726438,0.00001883411,0.0001089954,0.000021942,0.000005727642,0.00003320608,0.000009336864,0.00003338084,0.9989526,0.000143707,0.00002977539,0.0005851934],"study_design_scores_gemma":[0.00001667265,0.00009499831,0.002956097,0.000006080474,0.00001884823,0.0002799112,0.00002118622,0.001174666,0.9920208,0.00005275107,0.0033538,0.000004288474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881935,0.00150112,0.005433895,0.00008902195,0.00004530176,0.00004901989,0.001216677,0.0002395748,0.003231904],"genre_scores_gemma":[0.9898813,0.0004139408,0.002563947,0.00004932172,0.00001014285,0.00005771718,0.002100834,0.00009111987,0.004831665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003381454,"threshold_uncertainty_score":0.01131213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0462069993200496,"score_gpt":0.2215842216391591,"score_spread":0.1753772223191095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}