{"id":"W2150973554","doi":"10.1093/hmg/ddt081","title":"Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; PKD Australia; Kidney Foundation of Canada","keywords":"PKD1; Biology; Autosomal dominant polycystic kidney disease; Transgene; Polycystic kidney disease; Genetically modified mouse; Kidney; Extracellular; Cell biology; Internal medicine; Endocrinology; Cancer research; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004859271,0.0009085836,0.0004991043,0.001178857,0.0003787527,0.0005655813,0.0005541402,0.001343793,0.001930262],"category_scores_gemma":[0.0002092299,0.0004733767,0.0005895582,0.0004141738,0.0006570547,0.000561479,0.0004794548,0.002060174,0.0007523851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004825713,"about_ca_system_score_gemma":0.0003554148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000408233,"about_ca_topic_score_gemma":0.0005032368,"domain_scores_codex":[0.9994445,0.00009215967,0.00009187822,0.0001479113,0.0001319717,0.00009155896],"domain_scores_gemma":[0.9996487,0.00004285569,0.0000922843,0.00005431274,0.00003412348,0.0001278343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003675215,0.0003129716,0.0003363389,0.00007655157,0.00001607942,0.0003637107,0.00005187247,0.0001490095,0.9960414,0.0006563254,0.0001301676,0.001498115],"study_design_scores_gemma":[0.0002872224,0.002442779,0.005744698,0.00005655373,0.0001041637,0.004594731,0.00007966528,0.004038685,0.9713327,0.0005496821,0.01073433,0.00003467901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774571,0.002122968,0.01332221,0.0005021254,0.0002153362,0.0002930807,0.001893617,0.000647678,0.003545962],"genre_scores_gemma":[0.96597,0.002657651,0.01375365,0.0002848831,0.00005956777,0.0008219326,0.002657839,0.0001386964,0.01365587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930262,"threshold_uncertainty_score":0.006457388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236137232386763,"score_gpt":0.2483366506463118,"score_spread":0.2359752783224442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}