{"id":"W2151091046","doi":"10.1073/pnas.0905654106","title":"Amyloid-β <sub>42</sub> signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre; University of Ottawa","funders":"Canadian Institutes of Health Research; Ontario Genomics Institute; Ontario Genomics; Alzheimer Society; Heart and Stroke Foundation of Canada","keywords":"Hyperphosphorylation; Neuroscience; Metabolism; Amyloid (mycology); Chemistry; Biology; Medicine; Biochemistry; Pathology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106995,0.0004560848,0.0002542167,0.0001899136,0.0001387001,0.0003411374,0.0001245574,0.0002465222,0.0005236981],"category_scores_gemma":[0.00009199406,0.0001307381,0.0001806882,0.0001335436,0.0002768042,0.0002353987,0.0002274234,0.0004031052,0.0002598295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002262967,"about_ca_system_score_gemma":0.0002068053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004747115,"about_ca_topic_score_gemma":0.0009677366,"domain_scores_codex":[0.9999226,0.000009491841,0.000007076498,0.00001706436,0.0000220734,0.00002171871],"domain_scores_gemma":[0.9999433,0.000006880039,0.00002189953,0.000006464228,0.000009635172,0.00001182254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000492519,0.00000463626,0.0001301901,0.00001495822,0.000003684674,0.00003177856,0.000005545549,0.00001565696,0.9991948,0.00002721425,0.00001016417,0.0005121788],"study_design_scores_gemma":[0.000005615795,0.0001407388,0.006184596,0.000006281754,0.00001536012,0.0003284896,0.00003704788,0.0003311468,0.9915977,0.00009659621,0.001252778,0.000003611701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941955,0.002039842,0.002516892,0.0000872394,0.00002038388,0.00002382953,0.0003334162,0.00007976723,0.0007030923],"genre_scores_gemma":[0.9924213,0.00261377,0.003154379,0.00008529738,0.00001087467,0.00005067128,0.0004149553,0.00002534109,0.001223383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005236981,"threshold_uncertainty_score":0.0017519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198400315398565,"score_gpt":0.31959985590714,"score_spread":0.2876158527531543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}