{"id":"W2151096260","doi":"10.1093/molbev/msu146","title":"A Small System—High-Resolution Study of Metabolic Adaptation in the Central Metabolic Pathway to Temperate Climates in Drosophila melanogaster","year":2014,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Genetics; Single-nucleotide polymorphism; Drosophila melanogaster; Population; Local adaptation; Gene; Natural selection; Evolutionary biology; Balancing selection; Genetic variation; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280322,0.00009638305,0.0002126617,0.0001330189,0.000240613,0.000219571,0.0002073265,0.0001487053,0.0007902928],"category_scores_gemma":[0.0001635952,0.0001271735,0.0001962691,0.0001530509,0.0002040412,0.0001812407,0.0002899161,0.0002763821,0.0001039453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000431519,"about_ca_system_score_gemma":0.0001994381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004712495,"about_ca_topic_score_gemma":0.01091898,"domain_scores_codex":[0.9999424,0.00001164484,0.00000260118,0.00002893411,0.000007881185,0.000006464549],"domain_scores_gemma":[0.9999017,0.00002903033,0.00002001127,0.00002049972,0.00000839112,0.00002042402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001276346,0.00003805153,0.01660486,0.000054223,0.00005932937,0.00006146663,0.00006555374,0.001700992,0.9760376,0.0004346647,0.0001188156,0.004696772],"study_design_scores_gemma":[0.00005728835,0.0003790386,0.8519676,0.000009013561,0.00009660752,0.000414307,0.000210622,0.03713698,0.1051828,0.0008289077,0.003674784,0.00004192873],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930026,0.0001831207,0.005967645,0.00002835568,0.000004693794,0.00001206143,0.0002345518,0.00004070993,0.0005263488],"genre_scores_gemma":[0.9924169,0.00008308186,0.006741772,0.00003581327,0.000003407496,0.00002338948,0.0003143234,0.00001374019,0.0003675761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004712495,"threshold_uncertainty_score":0.009370148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507844630880431,"score_gpt":0.2671711134463986,"score_spread":0.2420926671375943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}