{"id":"W2151111659","doi":"10.1016/s0300-9084(02)00025-1","title":"Pathways to motor neuron degeneration in transgenic mouse models","year":2002,"lang":"en","type":"review","venue":"Biochimie","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Peripherin; SOD1; Amyotrophic lateral sclerosis; Neurofilament; Genetically modified mouse; Motor neuron; Transgene; Biology; Cell biology; Mutant; Intermediate filament; Neuroscience; Genetics; Cytoskeleton; Gene; Pathology; Disease; Immunology; Medicine; Spinal cord; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002002992,0.0004406424,0.00132355,0.0005099274,0.00004849135,0.00004218312,0.0002814868,0.0004368887,0.0002361603],"category_scores_gemma":[0.00005375001,0.0003399344,0.0004241299,0.0005494599,0.00003083632,0.00008121443,0.00007484348,0.0005921114,0.0005128649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004331973,"about_ca_system_score_gemma":0.0002465885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003984534,"about_ca_topic_score_gemma":0.00002548558,"domain_scores_codex":[0.9973222,0.0002062165,0.0006887,0.0006858165,0.000547449,0.0005496056],"domain_scores_gemma":[0.9988067,0.00004314286,0.00008565485,0.0006357494,0.00005628104,0.0003724427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006742983,0.0003507154,0.000001931855,0.008355535,0.00006769312,0.00006335058,0.0001619854,0.00006628141,0.00481644,0.0001578737,0.002306262,0.9835845],"study_design_scores_gemma":[0.001547493,0.001206524,0.0001246778,0.01176807,0.0005081288,0.00005103783,0.000004335538,0.001590439,0.0003002363,0.00004065569,0.9817771,0.001081295],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005984745,0.9898341,0.0001349343,0.000204741,0.0001293777,0.00297634,0.0001072028,0.00008880788,0.0005397884],"genre_scores_gemma":[0.001328855,0.9943076,0.0005479346,0.0001956728,0.0003806631,0.0004196599,0.0001659406,0.0001280621,0.002525577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9825032,"threshold_uncertainty_score":0.9999053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2135278840578241,"score_gpt":0.3500110793419759,"score_spread":0.1364831952841518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}