{"id":"W2151115143","doi":"10.2337/db15-0963","title":"Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Lawson Health Research Institute; Western University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Natural Science Foundation of China; National Heart, Lung, and Blood Institute; University of Washington","keywords":"Calpain; Calpastatin; Mitochondrion; Diabetic cardiomyopathy; ATP synthase; Mitochondrial ROS; Internal medicine; Endocrinology; Reactive oxygen species; Streptozotocin; Downregulation and upregulation; Oxidative stress; Superoxide; Cell biology; Biology; Chemistry; Cardiomyopathy; Biochemistry; Medicine; Diabetes mellitus; Enzyme; Heart failure; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002637496,0.000574188,0.0003148579,0.0002567008,0.0002084309,0.0003272603,0.0003248992,0.0004954821,0.0008027477],"category_scores_gemma":[0.0001199775,0.0001375691,0.0003733309,0.0001382824,0.0002785802,0.0003497339,0.0002791319,0.0008010223,0.0001268404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003341623,"about_ca_system_score_gemma":0.0001599267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001884049,"about_ca_topic_score_gemma":0.0003153798,"domain_scores_codex":[0.9998869,0.00001405608,0.00001051161,0.00003282135,0.0000269811,0.00002881882],"domain_scores_gemma":[0.9998674,0.00001008278,0.0000679567,0.000009214244,0.00001345999,0.00003185744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002460013,0.000113909,0.001463493,0.0001567152,0.00002632972,0.0007471113,0.00003367418,0.00005959821,0.9931564,0.0003366424,0.0001602036,0.003499908],"study_design_scores_gemma":[0.0002372018,0.001358056,0.06249781,0.00005737421,0.0001624458,0.00567532,0.0001509438,0.002645941,0.9209465,0.0009880175,0.005260803,0.00001954548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771359,0.0116678,0.008824748,0.0005901135,0.000163152,0.00006335421,0.0001865235,0.0001158338,0.001252586],"genre_scores_gemma":[0.9932028,0.003702334,0.001746898,0.0001595232,0.0000519313,0.00002554414,0.0001714945,0.000007441294,0.0009319417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008027477,"threshold_uncertainty_score":0.002685487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01922273878115365,"score_gpt":0.2435446051766953,"score_spread":0.2243218663955417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}