{"id":"W2151123904","doi":"10.1084/jem.20091808","title":"Viral adaptation to immune selection pressure by HLA class I–restricted CTL responses targeting epitopes in HIV frameshift sequences","year":2010,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Freiwillige Akademische Gesellschaft; National Institutes of Health; National Science Foundation","keywords":"Biology; CTL*; Epitope; Virology; Human leukocyte antigen; Cytotoxic T cell; Immune system; CD8; Antigen; Immunology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003722587,0.0001731864,0.0001354187,0.0001526485,0.0001000155,0.0003287936,0.00009334724,0.0001962676,0.001140874],"category_scores_gemma":[0.0005688592,0.0001202146,0.0001088788,0.00007177774,0.0002533761,0.0001196028,0.0001628829,0.0003160007,0.0002130705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009630543,"about_ca_system_score_gemma":0.00007725933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001041969,"about_ca_topic_score_gemma":0.00008735577,"domain_scores_codex":[0.9997688,0.00009561035,0.00001113122,0.00003802239,0.00002909315,0.00005745334],"domain_scores_gemma":[0.9996941,0.0001095434,0.0000606688,0.00005142294,0.00002597304,0.00005835625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009585458,0.00026167,0.1120266,0.00003542268,0.00004204598,0.0003377954,0.0001538251,0.0003184954,0.8621166,0.0002407495,0.00008464152,0.02342378],"study_design_scores_gemma":[0.0001699316,0.00517328,0.7311208,0.00002509409,0.000120231,0.009732948,0.0004314914,0.004347618,0.2457504,0.0007102881,0.002397122,0.00002081969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995794,0.0000541198,0.000152131,0.000007025587,0.000001511301,0.000001931698,0.000003911816,0.00000318738,0.0001967893],"genre_scores_gemma":[0.9996735,0.00002268079,0.0001204377,0.00001416766,0.000005872168,0.000001840117,0.00001660179,0.000001315108,0.0001436521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140874,"threshold_uncertainty_score":0.003816545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241688316736961,"score_gpt":0.2981472993969382,"score_spread":0.2857304162295686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}