{"id":"W2151123904","doi":"10.1084/jem.20091808","title":"Viral adaptation to immune selection pressure by HLA class I–restricted CTL responses targeting epitopes in HIV frameshift sequences","year":2010,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Freiwillige Akademische Gesellschaft; National Institutes of Health; National Science Foundation","keywords":"Biology; CTL*; Epitope; Virology; Human leukocyte antigen; Cytotoxic T cell; Immune system; CD8; Antigen; Immunology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007028735,0.0001309211,0.0002520431,0.0001797831,0.0001576079,0.000009173458,0.0002291402,0.0001050407,0.0005356401],"category_scores_gemma":[0.0004555321,0.00007473482,0.00003634113,0.0001894392,0.0002185555,0.0001277359,0.00003681215,0.0006394706,0.00005159912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000519229,"about_ca_system_score_gemma":0.00007502473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006492917,"about_ca_topic_score_gemma":0.00003913188,"domain_scores_codex":[0.9985701,0.0005105564,0.0004299587,0.0001055909,0.0001265009,0.000257336],"domain_scores_gemma":[0.9992005,0.0003570528,0.0002074766,0.00009882395,0.00008387701,0.00005229587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0019711,0.0001669262,0.0009597669,0.000002510062,0.0001012222,0.00001180048,0.005341183,0.00002151366,0.9844939,0.00002911478,0.006066523,0.0008344181],"study_design_scores_gemma":[0.003010176,0.003031028,0.006920737,0.00009647515,0.00004646001,0.0002107795,0.008498734,0.00002773542,0.9586772,0.00003236908,0.01934711,0.0001011969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803607,0.01535831,0.00007305642,0.003322146,0.0004832272,0.0002374537,0.00001342168,0.00001098467,0.0001407091],"genre_scores_gemma":[0.9987394,0.0001501491,0.0002003337,0.00009516239,0.0001211901,0.00001174962,0.00002892055,0.000009062104,0.0006440943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02581672,"threshold_uncertainty_score":0.5864883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241688316736961,"score_gpt":0.2981472993969382,"score_spread":0.2857304162295686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}