{"id":"W2151124650","doi":"10.1124/dmd.108.021162","title":"Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved with Wheat Protein Extract","year":2008,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Liver physiology and pathology","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cryopreservation; Cytochrome P450; Cryoprotectant; CYP2E1; Hepatocyte; Biology; Drug metabolism; Toxicity; CYP1A2; Isozyme; Biochemistry; Dimethyl sulfoxide; In vitro; CYP3A; Pharmacology; Cell biology; Metabolism; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749345,0.0002534747,0.000300315,0.0002081536,0.0002583646,0.0002495614,0.0001559532,0.00018252,0.001674453],"category_scores_gemma":[0.0001888848,0.0001124221,0.0003488029,0.0003652502,0.0002662537,0.0003886379,0.0001333883,0.0006095649,0.000328263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417815,"about_ca_system_score_gemma":0.0002473753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001865814,"about_ca_topic_score_gemma":0.002183582,"domain_scores_codex":[0.9999042,0.000017843,0.00001069585,0.00002498814,0.00001476595,0.00002745402],"domain_scores_gemma":[0.999878,0.0000339307,0.00001493067,0.000024916,0.00003026093,0.00001789416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004087258,0.0001127478,0.003707604,0.00005396229,0.00004666005,0.0001601672,0.0001114767,0.0001551733,0.9874167,0.0001186825,0.00009064069,0.003939004],"study_design_scores_gemma":[0.00005138892,0.001424324,0.04711616,0.000008854056,0.0001203175,0.0003467572,0.0001960074,0.001360169,0.9481012,0.0001066058,0.001156359,0.00001170098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996298,0.001267306,0.0008879465,0.00005913925,0.00005843866,0.00001249623,0.0004701241,0.0000134953,0.000933066],"genre_scores_gemma":[0.9936904,0.0005985962,0.0009614707,0.00004641697,0.00002809715,0.00002570331,0.001258524,0.00001225137,0.003378566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865814,"threshold_uncertainty_score":0.005601585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382077134632585,"score_gpt":0.2385738122308398,"score_spread":0.224753040884514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}