{"id":"W2151124650","doi":"10.1124/dmd.108.021162","title":"Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved with Wheat Protein Extract","year":2008,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Liver physiology and pathology","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cryopreservation; Cytochrome P450; Cryoprotectant; CYP2E1; Hepatocyte; Biology; Drug metabolism; Toxicity; CYP1A2; Isozyme; Biochemistry; Dimethyl sulfoxide; In vitro; CYP3A; Pharmacology; Cell biology; Metabolism; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627444,0.000172083,0.0005576393,0.0001577473,0.00008612544,0.000003914864,0.00005569541,0.0001104584,0.00004584058],"category_scores_gemma":[0.00001920461,0.0001200846,0.00006413765,0.0001923405,0.00024535,0.0003522025,0.00003253033,0.0002071754,0.000005761062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008347057,"about_ca_system_score_gemma":0.00006214302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003700904,"about_ca_topic_score_gemma":0.0000411681,"domain_scores_codex":[0.9990144,0.0001335075,0.0002044443,0.0002717929,0.0001500062,0.0002258114],"domain_scores_gemma":[0.9994738,0.00003939198,0.0001007334,0.0002335619,0.0000615871,0.00009099548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002677822,0.0005888945,0.04087718,0.0001496451,0.00006583079,0.0001224116,0.00145401,0.000005701384,0.9513041,0.001255174,0.00001677202,0.001482505],"study_design_scores_gemma":[0.002035764,0.0001306634,0.807986,0.00006389761,0.00009508341,0.00015578,0.0000415999,0.00008067267,0.1889084,0.0003190001,0.00007221496,0.0001109363],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965749,0.00206154,0.0001179788,0.0001507447,0.00002425746,0.0006169877,0.00002546547,0.000028247,0.0003998287],"genre_scores_gemma":[0.998666,0.0003566644,0.0005087978,0.00008334675,0.00008039309,0.00008888332,0.00005075781,0.00001382019,0.0001513174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7671088,"threshold_uncertainty_score":0.4896908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382077134632585,"score_gpt":0.2385738122308398,"score_spread":0.224753040884514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}