{"id":"W2151159311","doi":"10.1093/jac/dkt381","title":"Target optimization for peptide nucleic acid (PNA)-mediated antisense inhibition of the CmeABC multidrug efflux pump in Campylobacter jejuni","year":2013,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Alberta","keywords":"Peptide nucleic acid; Efflux; Multiple drug resistance; Campylobacter jejuni; Nucleic acid; Microbiology; Peptide; Antibiotics; Biology; Campylobacter; Antibiotic resistance; Bacteria; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002269284,0.000452681,0.0003350772,0.0001637121,0.0001440294,0.000238132,0.0002068488,0.0003385814,0.0009765825],"category_scores_gemma":[0.0002297694,0.0001853342,0.0002894237,0.000100907,0.0002091063,0.0001448574,0.0001653512,0.0004614499,0.0002772765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003324546,"about_ca_system_score_gemma":0.0002795226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000489852,"about_ca_topic_score_gemma":0.001083383,"domain_scores_codex":[0.9998345,0.00002160327,0.00001752547,0.00004459628,0.00005798197,0.00002378291],"domain_scores_gemma":[0.9998567,0.00003265545,0.00005465334,0.00000884914,0.00002895774,0.00001813488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003610107,0.00001968607,0.00003736737,0.00003318183,0.000002652973,0.00001004152,0.000004859377,0.0001666174,0.9990401,0.00002799327,0.00001335202,0.0006080841],"study_design_scores_gemma":[0.00001456323,0.0004476809,0.0004116022,0.000003441102,0.00001248946,0.00004419408,0.000007530752,0.0009549177,0.9970564,0.00001317889,0.001029646,0.000004337739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838116,0.001195083,0.01249463,0.00009518409,0.00006879162,0.0001733271,0.0003057343,0.0001100248,0.001745621],"genre_scores_gemma":[0.9822395,0.0009436388,0.01406602,0.00009114514,0.00001289954,0.0001832022,0.0004171644,0.00003312894,0.002013322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009765825,"threshold_uncertainty_score":0.00326705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009761539052961472,"score_gpt":0.2077714827413132,"score_spread":0.1980099436883518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}