{"id":"W2151187507","doi":"10.1210/me.2003-0441","title":"Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse","year":2004,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":355,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre; Université de Montréal","funders":"","keywords":"Biology; Chromatin immunoprecipitation; Genome; Chromatin; Gene; Conserved sequence; Genetics; Human genome; Estrogen receptor; Computational biology; Gene expression; Promoter; Peptide sequence; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693843,0.0001941358,0.0002163138,0.0007484387,0.0001710511,0.0002512694,0.0001701381,0.0003004209,0.001633903],"category_scores_gemma":[0.0001862671,0.0001830919,0.0002370756,0.0003492726,0.0001464127,0.00008262754,0.0002295356,0.0002484077,0.0004681915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368059,"about_ca_system_score_gemma":0.0001231672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004603734,"about_ca_topic_score_gemma":0.001090549,"domain_scores_codex":[0.9998239,0.00001691517,0.000008826976,0.00007796517,0.00004532211,0.0000272205],"domain_scores_gemma":[0.9998828,0.00002520665,0.00002828856,0.00001593133,0.00001424878,0.00003344613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002651432,0.00002710474,0.005343919,0.0000535037,0.00003262335,0.00007314455,0.00002607597,0.00005417838,0.9871913,0.0001388602,0.0001260762,0.006667987],"study_design_scores_gemma":[0.000100592,0.0005932196,0.5414625,0.00004297166,0.0002277683,0.00379915,0.00009013687,0.0006713814,0.4336542,0.0006133516,0.0187137,0.00003096187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842349,0.004511476,0.005111546,0.0001197504,0.00001382658,0.00003131355,0.003683601,0.0001404517,0.002153156],"genre_scores_gemma":[0.9743918,0.001979976,0.007701125,0.0002604972,0.00001480843,0.00006491429,0.01120667,0.00005430002,0.004326031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633903,"threshold_uncertainty_score":0.005465984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005159731421256139,"score_gpt":0.2426007596100923,"score_spread":0.2374410281888361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}