{"id":"W2151187507","doi":"10.1210/me.2003-0441","title":"Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse","year":2004,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":355,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre; Université de Montréal","funders":"","keywords":"Biology; Chromatin immunoprecipitation; Genome; Chromatin; Gene; Conserved sequence; Genetics; Human genome; Estrogen receptor; Computational biology; Gene expression; Promoter; Peptide sequence; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855444,0.0001493145,0.0001840464,0.000138396,0.00004668161,0.000008330217,0.0001612151,0.0001561783,0.000003391149],"category_scores_gemma":[0.0001195265,0.0001603196,0.00005587601,0.00009992922,0.0001378582,0.000003876371,0.0001390282,0.0001345417,0.000005867937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002836799,"about_ca_system_score_gemma":0.00004872835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006685476,"about_ca_topic_score_gemma":0.00001280897,"domain_scores_codex":[0.9987069,0.0001881577,0.0003598889,0.0003529797,0.00008876657,0.000303356],"domain_scores_gemma":[0.9994089,0.00001186017,0.000128395,0.0003515027,0.00004044272,0.0000589193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000261701,0.0001178455,0.006054742,0.00001214185,0.00006590426,0.00008157189,0.00003348002,0.0004202491,0.9916642,0.001147979,0.000002851372,0.0001373188],"study_design_scores_gemma":[0.001672104,0.0004438735,0.0399679,0.00000470107,0.00001945502,0.00004230181,0.00002232187,0.000001610531,0.9569414,0.0005716703,0.0001785403,0.000134086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978787,0.00104441,0.0005858149,0.0001417783,0.00003543101,0.0002466695,0.00001017392,0.00001246724,0.00004450031],"genre_scores_gemma":[0.999165,0.0001550009,0.0003793017,0.00007254161,0.0000115205,0.00002945811,0.0001038498,0.00002205057,0.00006125723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03472278,"threshold_uncertainty_score":0.6537644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005159731421256139,"score_gpt":0.2426007596100923,"score_spread":0.2374410281888361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}