{"id":"W2151189492","doi":"10.1534/genetics.114.164707","title":"The Principal Role of Ku in Telomere Length Maintenance Is Promotion of Est1 Association with Telomeres","year":2014,"lang":"en","type":"article","venue":"Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Cullen Foundation","keywords":"Telomere; Telomerase; Biology; Protein subunit; Cell biology; Saccharomyces cerevisiae; Telomerase RNA component; Telomere-binding protein; DNA; Genetics; Telomerase reverse transcriptase; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004710318,0.0001426932,0.0003149206,0.00009163718,0.00005188611,0.000009431737,0.0001481474,0.0001126312,0.00001627547],"category_scores_gemma":[0.0002737536,0.00009551432,0.00005349798,0.0003240365,0.0001167911,0.00003415616,0.00003590681,0.0001755744,0.000006395149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008629265,"about_ca_system_score_gemma":0.0001162214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006388907,"about_ca_topic_score_gemma":0.0003094746,"domain_scores_codex":[0.9984951,0.00007811822,0.0004223282,0.0002146788,0.000483349,0.0003064531],"domain_scores_gemma":[0.9987884,0.0001345327,0.000342764,0.000387086,0.0002805564,0.0000666155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001942916,0.0002532757,0.9113515,0.0001627196,0.00006605346,0.000002159088,0.001583245,0.00006759998,0.0268497,0.0006412134,0.0002363749,0.05859184],"study_design_scores_gemma":[0.001666232,0.0008823631,0.8040111,0.000261919,0.00006962398,0.00001215511,0.0006711428,0.001702148,0.1801766,0.0004624215,0.00991848,0.000165864],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970903,0.0004762671,0.00007886794,0.0007022816,0.00006049648,0.0003524151,0.00000960613,0.00001726867,0.001212516],"genre_scores_gemma":[0.9974128,0.0004754721,0.00139518,0.00006685624,0.0000699493,0.00001384959,0.000005916563,0.00002085832,0.0005391287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1533269,"threshold_uncertainty_score":0.3894961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007634533391590212,"score_gpt":0.2294446006624999,"score_spread":0.2218100672709097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}