{"id":"W2151189492","doi":"10.1534/genetics.114.164707","title":"The Principal Role of Ku in Telomere Length Maintenance Is Promotion of Est1 Association with Telomeres","year":2014,"lang":"en","type":"article","venue":"Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Cullen Foundation","keywords":"Telomere; Telomerase; Biology; Protein subunit; Cell biology; Saccharomyces cerevisiae; Telomerase RNA component; Telomere-binding protein; DNA; Genetics; Telomerase reverse transcriptase; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008261052,0.0003396994,0.0002268153,0.000108649,0.0002303909,0.0003808282,0.0001895008,0.0001954189,0.001767809],"category_scores_gemma":[0.0001179596,0.0001202401,0.0002447613,0.0001229999,0.0001578031,0.0002643989,0.0004338727,0.0003332918,0.0006166908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002450197,"about_ca_system_score_gemma":0.0001430263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002059573,"about_ca_topic_score_gemma":0.0003685809,"domain_scores_codex":[0.9998835,0.00001853624,0.00001308124,0.00003468731,0.00002891811,0.00002118666],"domain_scores_gemma":[0.9999089,0.00001386362,0.00002403124,0.00001844924,0.000011638,0.00002297039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006900526,0.00001142806,0.000507779,0.000040202,0.000004720697,0.00003962583,0.000007807022,0.00005627052,0.9980505,0.00008799425,0.00002287524,0.001101801],"study_design_scores_gemma":[0.000004457981,0.00009618056,0.01202896,0.000005998731,0.00000856813,0.000234065,0.00001697563,0.0004399137,0.9850426,0.00004447155,0.002073215,0.000004542483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927375,0.00250898,0.002980262,0.00005364279,0.00001802365,0.000006911977,0.0002347808,0.0001116042,0.001348315],"genre_scores_gemma":[0.9950818,0.0006791879,0.001029731,0.00002470118,0.000006073771,0.00001093742,0.0005032765,0.0000204869,0.002643823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001767809,"threshold_uncertainty_score":0.005913913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007634533391590212,"score_gpt":0.2294446006624999,"score_spread":0.2218100672709097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}