{"id":"W2151209400","doi":"10.1073/pnas.1108799108","title":"Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; National Institute on Drug Abuse; McKnight Foundation","keywords":"Ubiquitin ligase; DNA ligase; Molecular biology; DDB1; DNA repair; Ubiquitin; Biology; Ku70; DNA damage; Cell biology; Biochemistry; Chemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009061358,0.0005000593,0.0004284026,0.0003344013,0.0003511399,0.0006213789,0.0003293646,0.0003172489,0.001004815],"category_scores_gemma":[0.00007303115,0.0001758633,0.0004607442,0.0002734154,0.0002276273,0.0002675741,0.0003308462,0.0003723639,0.0008926908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005745698,"about_ca_system_score_gemma":0.0002200599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005293089,"about_ca_topic_score_gemma":0.0005944395,"domain_scores_codex":[0.9998856,0.000007047504,0.000008407349,0.00003851807,0.00003475327,0.00002559293],"domain_scores_gemma":[0.9999249,0.000004385334,0.00002470174,0.000009045079,0.00001111459,0.00002594403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001866619,0.00004689519,0.003903963,0.0001406973,0.00003843305,0.0002747694,0.00002012192,0.0002738067,0.9816228,0.00055262,0.0004961982,0.01244312],"study_design_scores_gemma":[0.00001312241,0.0001792508,0.01336233,0.000009306395,0.00004727638,0.00192259,0.00003795436,0.001381703,0.9510348,0.0001743943,0.03182117,0.00001610674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9087256,0.02289104,0.05234186,0.0003383855,0.0002065603,0.0001204052,0.002998877,0.00125205,0.01112521],"genre_scores_gemma":[0.9652756,0.006209538,0.01296807,0.0001903731,0.0000254434,0.00003033208,0.004835732,0.00004030983,0.01042447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004815,"threshold_uncertainty_score":0.004168868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1049182062704579,"score_gpt":0.3338820552357509,"score_spread":0.228963848965293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}