{"id":"W2151216635","doi":"10.1016/j.tibs.2009.10.009","title":"Origins and evolution of the mechanisms regulating translation initiation in eukaryotes","year":2009,"lang":"en","type":"review","venue":"Trends in Biochemical Sciences","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Translation (biology); Biology; Eukaryotic translation; Translational regulation; Eukaryotic translation initiation factor 4 gamma; Initiation factor; Lineage (genetic); Computational biology; Evolutionary biology; Genetics; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008063728,0.001139355,0.001632816,0.001574387,0.0003796997,0.001664752,0.001717101,0.001561762,0.001623364],"category_scores_gemma":[0.0007412646,0.0005279414,0.0004149897,0.002868328,0.001435344,0.001862178,0.001077822,0.001606776,0.001857184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001366977,"about_ca_system_score_gemma":0.001158661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121356,"about_ca_topic_score_gemma":0.0015431,"domain_scores_codex":[0.9997508,0.0000227824,0.00003665233,0.00007209894,0.00008227175,0.00003534491],"domain_scores_gemma":[0.9996113,0.0001482047,0.00009602574,0.00001844266,0.00008956176,0.00003635887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002052979,0.00004179014,0.0004110069,0.009939124,0.00007067999,0.0003455445,0.0001135559,0.001227546,0.01493241,0.01169594,0.009581576,0.9514355],"study_design_scores_gemma":[0.00003505553,0.0000743229,0.002736406,0.002394734,0.000138592,0.001438995,0.000139729,0.0003174985,0.005244846,0.01211719,0.9753161,0.00004646354],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004740559,0.9976239,0.0005576442,0.0002246534,0.0001732864,0.000003621914,0.00002334541,0.00001725409,0.0009023155],"genre_scores_gemma":[0.001831794,0.9968471,0.0005213802,0.0001136441,0.0001714378,0.000004311644,0.00004052511,0.000002253882,0.0004675676],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001717101,"threshold_uncertainty_score":0.009918153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04949939717119584,"score_gpt":0.327682603414199,"score_spread":0.2781832062430031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}