{"id":"W2151217371","doi":"10.1124/mol.108.052860","title":"Multiple Roles of Charged Amino Acids in Cytoplasmic Loop 7 for Expression and Function of the Multidrug and Organic Anion Transporter MRP1 (ABCC1)","year":2008,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"ABCC1; Transporter; Cytoplasm; Function (biology); Expression (computer science); Organic anion transporter 1; Loop (graph theory); Chemistry; Amino acid; Ion; Multidrug Resistance-Associated Proteins; ATP-binding cassette transporter; Biochemistry; Biology; Cell biology; Gene; Computer science; Organic chemistry; Mathematics; Combinatorics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001171281,0.0001269121,0.0003069282,0.00009041862,0.00004850814,8.494102e-7,0.00005266184,0.0001138805,0.00003824412],"category_scores_gemma":[0.000007376896,0.00009220064,0.00007011515,0.00009554394,0.0001378494,0.00003552898,0.00001236315,0.0001227499,2.807183e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000132805,"about_ca_system_score_gemma":0.00003795644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005482685,"about_ca_topic_score_gemma":0.00002707418,"domain_scores_codex":[0.9991826,0.00004773815,0.0002755444,0.000216398,0.0001144184,0.0001632755],"domain_scores_gemma":[0.9996604,0.00003124712,0.00009797327,0.0001070961,0.00005169529,0.00005154235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060215,0.0001685519,0.04871422,0.0002142741,0.00003647887,0.00002350739,0.0006128871,0.00001027287,0.9486573,0.00001123785,0.00002110079,0.0004700091],"study_design_scores_gemma":[0.006238788,0.0001860684,0.1062938,0.00006139085,0.0001482856,0.0000220418,0.00009396507,0.0005570463,0.8860745,0.0000239024,0.000225171,0.00007499302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940153,0.0006633386,0.004224257,0.0001789782,0.0001669908,0.0007060394,0.00001715124,0.00001209744,0.00001588561],"genre_scores_gemma":[0.9989496,0.0002576147,0.0004363708,0.0001729372,0.00002068734,0.00003735826,0.00002150283,0.00002036125,0.00008355073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06258275,"threshold_uncertainty_score":0.3759833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009249546317011647,"score_gpt":0.2347293938922413,"score_spread":0.2254798475752297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}