{"id":"W2151246040","doi":"10.2337/db09-0658","title":"Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Foundation for the Study of Diabetes","keywords":"In vivo; In vitro; Pancreatic islets; Homing (biology); Pancreas; Chemistry; Islet; Antibody; Phage display; Cell; Biodistribution; Cell biology; Biology; Molecular biology; Biochemistry; Insulin; Endocrinology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860529,0.0002245058,0.0005793133,0.0005962448,0.00004948278,0.00001949084,0.00008742969,0.0000860986,0.00005481898],"category_scores_gemma":[0.0006575009,0.0001877382,0.00005377581,0.0009491151,0.00004607666,0.00008712145,0.00002786457,0.00009720637,0.0000201745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126718,"about_ca_system_score_gemma":0.00004432664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002659803,"about_ca_topic_score_gemma":0.00000668822,"domain_scores_codex":[0.9985908,0.00003579283,0.0003734884,0.000380394,0.0002061009,0.000413408],"domain_scores_gemma":[0.9992451,0.0001501229,0.00009104657,0.0002434217,0.0001323987,0.000137918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007444099,0.0004993128,0.03716002,0.00003855802,0.00004656829,0.000004617152,0.000288546,0.00005160415,0.9495796,0.00004565672,0.009399869,0.002811193],"study_design_scores_gemma":[0.00136175,0.0008846091,0.004069436,0.0002698124,0.00007798187,0.000001290542,0.0001403649,0.002664516,0.989127,0.00001849336,0.001189964,0.0001947831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944924,0.0003437924,0.000248764,0.001282218,0.0001339356,0.0006010398,0.00005700877,0.000108617,0.002732264],"genre_scores_gemma":[0.9928595,0.00001320578,0.003643861,0.002239168,0.00006886242,0.00004859478,0.00002595523,0.00002218276,0.001078681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03954738,"threshold_uncertainty_score":0.765574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186399981574521,"score_gpt":0.2778282593526921,"score_spread":0.2559642595369468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}