{"id":"W2151246040","doi":"10.2337/db09-0658","title":"Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Foundation for the Study of Diabetes","keywords":"In vivo; In vitro; Pancreatic islets; Homing (biology); Pancreas; Chemistry; Islet; Antibody; Phage display; Cell; Biodistribution; Cell biology; Biology; Molecular biology; Biochemistry; Insulin; Endocrinology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002407693,0.0005067905,0.0002109046,0.0002185611,0.00009798291,0.0003399946,0.0002563041,0.0003228601,0.0009233939],"category_scores_gemma":[0.0001654741,0.000125526,0.0002243182,0.000130756,0.0001734536,0.0001743506,0.0001888563,0.0004925015,0.0004383789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334787,"about_ca_system_score_gemma":0.0001464691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002008057,"about_ca_topic_score_gemma":0.0002759518,"domain_scores_codex":[0.9998769,0.00001703116,0.000006705813,0.00003354077,0.0000385813,0.00002721402],"domain_scores_gemma":[0.9998964,0.00002273764,0.00002425807,0.000008450727,0.00002410207,0.00002397194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002667503,0.00002058262,0.0001480711,0.00003794727,0.000004737864,0.00002949713,0.00001146454,0.0002058797,0.9965857,0.0001120855,0.00006592459,0.002751281],"study_design_scores_gemma":[0.00001549099,0.0002103052,0.0006964003,0.00000449855,0.00001413997,0.0001596526,0.00000504608,0.002261078,0.993567,0.00004318219,0.003019442,0.000003766081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8956767,0.002738143,0.0972307,0.0001815584,0.00007446438,0.0001368189,0.0002514331,0.0004678522,0.003242406],"genre_scores_gemma":[0.9451761,0.001638857,0.04798222,0.0002043164,0.000036318,0.00009576115,0.0004826724,0.00006033949,0.004323458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009233939,"threshold_uncertainty_score":0.00308907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186399981574521,"score_gpt":0.2778282593526921,"score_spread":0.2559642595369468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}