{"id":"W2151298587","doi":"10.2174/187231211795305212","title":"In Vitro and In Vivo Biodistribution of ZRS1, a Stabilized Type I N-Acetoxymethyl Carbamate-Containing Combi-Molecule","year":2011,"lang":"en","type":"article","venue":"Drug Metabolism Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Biodistribution; In vivo; Chemistry; Carbamate; In vitro; Molecule; Pharmacology; Stereochemistry; Combinatorial chemistry; Organic chemistry; Biochemistry; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601752,0.0001334131,0.0003164313,0.00008243492,0.00001581484,0.000007982251,0.000109317,0.00007647977,0.00003613834],"category_scores_gemma":[0.00009403131,0.0001271206,0.00007747966,0.0002102342,0.00008779259,0.000006826961,0.00006948179,0.00008028767,9.354252e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001164829,"about_ca_system_score_gemma":0.00001526516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005618551,"about_ca_topic_score_gemma":0.00005093346,"domain_scores_codex":[0.9990484,0.00009976689,0.0002790108,0.0002757147,0.00008675372,0.0002103341],"domain_scores_gemma":[0.999622,0.00001632456,0.00009028496,0.0001927757,0.00002861147,0.00005001018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002930482,0.00005658724,0.002605853,0.00001327418,0.00002854033,0.000004001818,0.0002174531,0.000001986405,0.9964316,0.00001791079,0.0001016281,0.0002280732],"study_design_scores_gemma":[0.0007093654,0.00001049113,0.00302889,0.000009070925,0.00003233502,0.000001105577,0.0001319983,0.00003003378,0.9943665,0.00002412857,0.001515433,0.0001406451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984168,0.0009768393,0.00006132492,0.0002573281,0.00004713424,0.00008458625,0.00002998319,0.000004142864,0.0001218153],"genre_scores_gemma":[0.9989564,0.0001265673,0.0004320251,0.0003901924,0.00002705348,0.0000105537,0.00003440555,0.00001093475,0.00001182793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00206514,"threshold_uncertainty_score":0.518383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00915655796740604,"score_gpt":0.2161951285887026,"score_spread":0.2070385706212965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}