{"id":"W2151299944","doi":"10.1016/j.celrep.2014.10.064","title":"Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital; McGill University; Université de Montréal; McGill University Health Centre","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Azrieli Foundation; Wellcome Trust; Fondation Brain Canada; Eli Lilly and Company","keywords":"FMR1; Fragile X syndrome; EIF4E; Dendritic spine; Translation (biology); Biology; Phenotype; Synaptic plasticity; Eukaryotic initiation factor; Knockout mouse; Messenger RNA; Neuroscience; Genetics; Fragile x; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170371,0.000444488,0.0003422895,0.0002643518,0.0001469969,0.000272199,0.0002645837,0.0003293677,0.001430397],"category_scores_gemma":[0.0001703496,0.0001438878,0.0002211664,0.0001169735,0.0003603983,0.0001530198,0.000138162,0.0007183719,0.0003484667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002478411,"about_ca_system_score_gemma":0.0002428401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000479766,"about_ca_topic_score_gemma":0.0008785161,"domain_scores_codex":[0.9999079,0.00001522764,0.00001412324,0.00002121632,0.00001811421,0.0000234938],"domain_scores_gemma":[0.9998816,0.00002263173,0.00004773305,0.00001558311,0.000008363597,0.00002412993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004236482,0.0001705718,0.0001462137,0.00006113017,0.00001480695,0.00008772408,0.00001047745,0.0001582834,0.994287,0.0002873392,0.0001388704,0.004213919],"study_design_scores_gemma":[0.0001588823,0.001313246,0.002232804,0.00001131283,0.00003604507,0.0004002411,0.00003234506,0.001280866,0.9909877,0.0001328042,0.003405658,0.000008111351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911851,0.001226009,0.004300533,0.0003219532,0.0001740633,0.0000921156,0.0006134118,0.0003382701,0.00174851],"genre_scores_gemma":[0.9919124,0.001360393,0.003691942,0.00007428349,0.00003299228,0.00008063758,0.0003673181,0.00004662123,0.002433453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430397,"threshold_uncertainty_score":0.00478512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0085031777819132,"score_gpt":0.2165540408056147,"score_spread":0.2080508630237015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}