{"id":"W2151322144","doi":"10.1128/jvi.02223-10","title":"Helix-Destabilizing, β-Branched, and Polar Residues in the Baboon Reovirus p15 Transmembrane Domain Influence the Modularity of FAST Proteins","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Nova Scotia Health Research Foundation","keywords":"Biology; Transmembrane domain; Ectodomain; Transmembrane protein; Fusion protein; Context (archaeology); Protein structure; Membrane protein; Cell biology; Biochemistry; Computational biology; Amino acid; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002310288,0.0003932401,0.0001893614,0.0001312116,0.0001099524,0.0002904769,0.0001802331,0.000288341,0.0007579908],"category_scores_gemma":[0.0002654074,0.0001828341,0.000307397,0.00009342793,0.0003669282,0.0002133645,0.0002699742,0.0004359211,0.0002716973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171209,"about_ca_system_score_gemma":0.0001837571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005842461,"about_ca_topic_score_gemma":0.00053855,"domain_scores_codex":[0.9998449,0.00004442805,0.00002052483,0.00002369776,0.00002283839,0.000043514],"domain_scores_gemma":[0.9997539,0.00007402867,0.00005789249,0.00001786858,0.00001454317,0.00008169259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001449856,0.00002070762,0.0002883847,0.00001129934,0.000006259941,0.00007937981,0.00001030712,0.00009514492,0.9989731,0.00006811546,0.000004128191,0.000298147],"study_design_scores_gemma":[0.00003776485,0.0004351005,0.007777286,0.000008252713,0.00003800871,0.0004904422,0.00005971306,0.00217584,0.9881621,0.00007592963,0.0007280369,0.00001153433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992423,0.0001058407,0.0003941292,0.000008580075,0.000004396187,0.000006089072,0.00002239913,0.000006912428,0.0002092402],"genre_scores_gemma":[0.999369,0.00007106551,0.0002980515,0.00001646528,0.000001462499,0.000003654814,0.00004552771,0.000008960295,0.0001859011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007579908,"threshold_uncertainty_score":0.00253576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486664019600185,"score_gpt":0.2353714546370377,"score_spread":0.2205048144410358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}