{"id":"W2151322144","doi":"10.1128/jvi.02223-10","title":"Helix-Destabilizing, β-Branched, and Polar Residues in the Baboon Reovirus p15 Transmembrane Domain Influence the Modularity of FAST Proteins","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Nova Scotia Health Research Foundation","keywords":"Biology; Transmembrane domain; Ectodomain; Transmembrane protein; Fusion protein; Context (archaeology); Protein structure; Membrane protein; Cell biology; Biochemistry; Computational biology; Amino acid; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00088314,0.0001168442,0.0002123057,0.00006008926,0.00004754004,0.000008648032,0.0004035783,0.0001531536,0.00001097981],"category_scores_gemma":[0.00007715232,0.0000654676,0.00008882802,0.00007073845,0.0002973318,0.00001287794,0.00004336013,0.000272196,7.170094e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004748732,"about_ca_system_score_gemma":0.00005881963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001789589,"about_ca_topic_score_gemma":0.0003367849,"domain_scores_codex":[0.9988319,0.0003308482,0.0003990961,0.0001425933,0.0001242026,0.0001714085],"domain_scores_gemma":[0.9993282,0.00003055823,0.0002434115,0.0002649435,0.00009867022,0.00003421206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007380032,0.0001072931,0.0126576,0.00002204277,0.00004418276,0.00002238396,0.002145982,0.00001852327,0.982959,0.0001295733,0.0000337474,0.001121645],"study_design_scores_gemma":[0.001526402,0.00414401,0.2567817,0.00005481576,0.00006134008,0.0006397513,0.001512165,0.00001186659,0.7271112,0.005530972,0.002427555,0.0001982121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952411,0.003217042,0.0004072168,0.0007910134,0.00004432303,0.0001482441,0.000007472629,0.000001047521,0.0001425411],"genre_scores_gemma":[0.9976881,0.001021436,0.0005237598,0.0006793046,0.00006579167,0.000005375663,0.000001288865,0.000007185823,0.000007816474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2558478,"threshold_uncertainty_score":0.2669691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486664019600185,"score_gpt":0.2353714546370377,"score_spread":0.2205048144410358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}