{"id":"W2151324457","doi":"10.1093/nass/nrn241","title":"Toward the discovery of new antifungal agents: The design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Symposium Series","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Phosphoramidite; Synthon; Chemistry; Regioselectivity; RNA; Silylation; Combinatorial chemistry; Phosphotransferase; Stereochemistry; Ligand (biochemistry); Chemical library; Biochemistry; Oligonucleotide; Enzyme; Receptor; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003925191,0.0001929544,0.0002211546,0.00002066711,0.0001983502,0.00004386442,0.0002131071,0.0001293066,0.000005494389],"category_scores_gemma":[0.00005719644,0.0001214294,0.00007088487,0.00008323917,0.0003485401,0.00004713392,0.0001085716,0.00007686835,2.450824e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004602234,"about_ca_system_score_gemma":0.00007578085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007842407,"about_ca_topic_score_gemma":0.000002634195,"domain_scores_codex":[0.9989347,0.0001403245,0.0002782462,0.0002784867,0.0001929704,0.0001753121],"domain_scores_gemma":[0.9993744,0.00005451519,0.000140595,0.0003234888,0.00006332052,0.00004363958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000319135,0.00004000411,0.0005302012,0.00004369438,0.00008915778,0.000001657256,0.001402665,0.000155534,0.9956867,0.0006004769,0.0001203472,0.001010411],"study_design_scores_gemma":[0.0005494636,0.0003545473,0.001157467,0.00005492779,0.00005263252,0.00004060104,0.0003854656,0.00007998531,0.9964641,0.000155614,0.0005549202,0.0001503213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7931592,0.0005697729,0.2046717,0.0009673759,0.00006845803,0.0004309176,0.00002940378,0.000008389134,0.000094787],"genre_scores_gemma":[0.985366,0.001997428,0.01210761,0.0001534644,0.00007673573,0.00001992894,0.00002075582,0.00002655594,0.0002315638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1925641,"threshold_uncertainty_score":0.4951748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937140009681996,"score_gpt":0.2305558520387627,"score_spread":0.2011844519419427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}