{"id":"W2151324457","doi":"10.1093/nass/nrn241","title":"Toward the discovery of new antifungal agents: The design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Symposium Series","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Phosphoramidite; Synthon; Chemistry; Regioselectivity; RNA; Silylation; Combinatorial chemistry; Phosphotransferase; Stereochemistry; Ligand (biochemistry); Chemical library; Biochemistry; Oligonucleotide; Enzyme; Receptor; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005580112,0.0006829567,0.0006490422,0.0003309166,0.0002364043,0.0007738416,0.0005521672,0.0009855813,0.0007586606],"category_scores_gemma":[0.0004799988,0.0003148027,0.0002918279,0.0003375359,0.0004493728,0.0004811183,0.0003243381,0.001027572,0.0005140699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004269136,"about_ca_system_score_gemma":0.0004887678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003680091,"about_ca_topic_score_gemma":0.0007477614,"domain_scores_codex":[0.9996512,0.00007101849,0.00002006633,0.0000724199,0.0001486348,0.00003678184],"domain_scores_gemma":[0.9997622,0.00009656539,0.00004479321,0.00002272873,0.00004338337,0.00003028318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004669758,0.00004294146,0.0001327835,0.00005437028,0.000004202979,0.00005199005,0.00001809644,0.0003361973,0.9933502,0.0001797694,0.00007074484,0.005712109],"study_design_scores_gemma":[0.00001805052,0.0003166207,0.0003837683,0.000003063664,0.00001090917,0.0002220419,0.000009827406,0.001484262,0.9949649,0.0000692055,0.002510263,0.000007031245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8134907,0.007577549,0.1712305,0.0008611442,0.00009724931,0.000558763,0.001201898,0.0007792179,0.004202984],"genre_scores_gemma":[0.8114656,0.005740477,0.1750786,0.0004489225,0.00008179383,0.0004751655,0.001947368,0.00008918479,0.004672746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009855813,"threshold_uncertainty_score":0.003097534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937140009681996,"score_gpt":0.2305558520387627,"score_spread":0.2011844519419427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}