{"id":"W2151397579","doi":"10.2337/db05-1455","title":"Suppressed Insulin Signaling and Increased Apoptosis in<i>Cd38</i>-Null Islets","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Glucose homeostasis; Endocrinology; Insulin; Internal medicine; CD38; Pancreatic islets; Biology; Signal transduction; Insulin receptor; Context (archaeology); Homeostasis; Apoptosis; Cell biology; Islet; Insulin resistance; Biochemistry; Stem cell; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002163729,0.0001638497,0.0001987623,0.00007733529,0.00005458894,0.00004270857,0.0001079248,0.0001287376,0.00002201345],"category_scores_gemma":[0.0001026763,0.0001641768,0.0000630272,0.0001094173,0.00006872502,0.000004798251,0.00007070928,0.00008823413,0.000006668073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005265635,"about_ca_system_score_gemma":0.00001829582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093621,"about_ca_topic_score_gemma":0.00001059117,"domain_scores_codex":[0.9989729,0.0000754474,0.0002204097,0.0003325213,0.00009796414,0.0003007549],"domain_scores_gemma":[0.9995932,0.00005257309,0.00005449994,0.000197762,0.00003882535,0.00006316672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002063965,0.00006019553,0.02725412,0.00001927487,0.0000138948,9.429049e-7,0.00001509604,0.00005062443,0.9709272,0.00003472726,0.0006904934,0.000912818],"study_design_scores_gemma":[0.0008390878,0.00005062775,0.01291614,0.00002222042,0.0000195887,5.895235e-7,0.00001409145,0.0001133268,0.9795767,0.0003267476,0.005903986,0.0002168629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958595,0.003422558,0.00002275788,0.00008882806,0.00009821118,0.00009518562,0.0000264294,0.00002130723,0.0003652281],"genre_scores_gemma":[0.9987974,0.00006664138,0.0003574327,0.0002631733,0.0002746482,0.0000199978,0.0001461169,0.00002625268,0.00004838972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01433798,"threshold_uncertainty_score":0.6694934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004535079053587882,"score_gpt":0.1991551049218228,"score_spread":0.1946200258682349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}