{"id":"W2151397579","doi":"10.2337/db05-1455","title":"Suppressed Insulin Signaling and Increased Apoptosis in<i>Cd38</i>-Null Islets","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Glucose homeostasis; Endocrinology; Insulin; Internal medicine; CD38; Pancreatic islets; Biology; Signal transduction; Insulin receptor; Context (archaeology); Homeostasis; Apoptosis; Cell biology; Islet; Insulin resistance; Biochemistry; Stem cell; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867899,0.0005190839,0.000425406,0.0004823941,0.0001728609,0.0004485003,0.0003587607,0.0003908808,0.003002868],"category_scores_gemma":[0.0002237033,0.0002482831,0.000230057,0.0001959791,0.0005648133,0.000344769,0.0003121384,0.0008982072,0.00063908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390392,"about_ca_system_score_gemma":0.000126867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002113888,"about_ca_topic_score_gemma":0.00022831,"domain_scores_codex":[0.9997191,0.00003132828,0.00003906944,0.00007370579,0.00008719587,0.00004951432],"domain_scores_gemma":[0.9996077,0.00004424206,0.000142825,0.000054688,0.00002559557,0.0001248085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002104291,0.00002332386,0.000223334,0.00001304462,0.000003116151,0.0001173647,0.000008734021,0.00002044289,0.9987813,0.00007172837,0.0000206224,0.0005067079],"study_design_scores_gemma":[0.00009689588,0.0004077672,0.007820675,0.000008680122,0.0000199089,0.002390735,0.00006232499,0.0006677207,0.9867329,0.0001653959,0.001617322,0.000009735414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971343,0.0003030279,0.001371562,0.00008876031,0.00002571334,0.000009694293,0.0002976027,0.00007673796,0.0006926049],"genre_scores_gemma":[0.9942483,0.000283727,0.001966584,0.00006989868,0.00001473466,0.00002804122,0.0003798325,0.0001026457,0.002906363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003002868,"threshold_uncertainty_score":0.01004565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004535079053587882,"score_gpt":0.1991551049218228,"score_spread":0.1946200258682349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}