{"id":"W2151462466","doi":"10.1126/science.1230612","title":"The Evolutionary Landscape of Alternative Splicing in Vertebrate Species","year":2012,"lang":"en","type":"article","venue":"Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Biology; Alternative splicing; RNA splicing; Exon; Intron; Evolutionary biology; Vertebrate; Genetics; Gene; Exonic splicing enhancer; Genome; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005303911,0.00003173081,0.00003344441,0.00003374117,0.0001062671,0.00001098695,0.0002287728,0.00001224612,0.000005011689],"category_scores_gemma":[0.000158309,0.00002072059,0.00001370389,0.0001842372,0.000287077,0.000009478049,0.0001102656,0.00003713517,0.000004631709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001078216,"about_ca_system_score_gemma":0.00006832917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001825744,"about_ca_topic_score_gemma":0.00002024826,"domain_scores_codex":[0.9994268,0.00001823875,0.00006615234,0.0000895814,0.0001619649,0.0002372255],"domain_scores_gemma":[0.9997448,0.00001444704,0.00002308359,0.0001300839,0.00004333328,0.00004420905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001123648,0.00001003454,0.140358,0.000001486416,0.000001497956,2.141401e-7,0.00005036552,0.00003617505,0.8577586,0.0009191033,0.00009875248,0.0007545541],"study_design_scores_gemma":[0.0001762821,0.00007959412,0.3242474,0.0000129858,8.119115e-7,0.00000478331,0.0004417906,0.003321209,0.6675944,0.0001402245,0.003910153,0.00007030619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958485,0.0008360842,0.00008155789,0.00008210346,0.00007791791,0.00004153444,0.000001235793,0.000001036951,0.003029971],"genre_scores_gemma":[0.9988191,0.0001341663,0.0001042138,0.00002016475,0.00005887069,0.000002620975,8.80949e-7,0.000001677727,0.0008583762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1901642,"threshold_uncertainty_score":0.1057747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487865700057388,"score_gpt":0.2824081755075082,"score_spread":0.2675295185069343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}