{"id":"W2151480309","doi":"10.1016/j.biopha.2006.08.003","title":"Protein tyrosine kinase signaling diversity and susceptibility to targeted kinase inhibitors","year":2006,"lang":"en","type":"review","venue":"Biomedicine & Pharmacotherapy","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Cancer Institute","keywords":"Receptor tyrosine kinase; Tyrosine kinase; Cancer research; Biology; Kinase; Signal transduction; JAK-STAT signaling pathway; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003710668,0.0005155494,0.001562173,0.001046205,0.0001104248,0.000485114,0.000457537,0.0004442533,0.001701169],"category_scores_gemma":[0.0004609623,0.0001596607,0.0002641923,0.001096842,0.0002692041,0.0006017101,0.0002826869,0.000615157,0.0006339493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003290978,"about_ca_system_score_gemma":0.0003564322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003837375,"about_ca_topic_score_gemma":0.0007915364,"domain_scores_codex":[0.9998884,0.00001814639,0.00001730315,0.00002292676,0.00003873559,0.00001445264],"domain_scores_gemma":[0.9998626,0.00006904503,0.00002944298,0.000005623853,0.00002477884,0.000008482464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002765895,0.00007572677,0.0005960003,0.004541573,0.0001247225,0.0005366016,0.00003490673,0.0005210189,0.007535767,0.002060814,0.009481284,0.974215],"study_design_scores_gemma":[0.0001359057,0.0005958246,0.006244614,0.001628506,0.0006331847,0.008830135,0.0001062755,0.0003691351,0.008289766,0.00316612,0.9699718,0.00002872979],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00136957,0.9964863,0.0002729282,0.0002172629,0.0001076439,0.000004802825,0.00002249151,0.000009967451,0.001509018],"genre_scores_gemma":[0.006769637,0.9915645,0.0002313797,0.0001869713,0.0001381978,0.000009275911,0.00004192681,0.000001383003,0.001056778],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001701169,"threshold_uncertainty_score":0.005690992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08842263659665611,"score_gpt":0.4154246812867952,"score_spread":0.3270020446901391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}