{"id":"W2151502110","doi":"10.1124/dmd.110.034835","title":"Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Gene isoform; Biology; Alternative splicing; Glucuronidation; Biochemistry; Enzyme; Glucuronosyltransferase; HEK 293 cells; Gene; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856239,0.0001351499,0.0002127705,0.00004186465,0.00007261065,0.00001344992,0.00009023335,0.00004232257,0.000006217282],"category_scores_gemma":[0.00006241886,0.00006787408,0.00003427497,0.0002272205,0.0001085789,0.0001115821,0.00003666042,0.0003558492,0.000001428369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001525347,"about_ca_system_score_gemma":0.0001096496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002541712,"about_ca_topic_score_gemma":0.00009754155,"domain_scores_codex":[0.9991547,0.00005834423,0.0001513797,0.0002381814,0.0002224814,0.0001748968],"domain_scores_gemma":[0.9994135,0.00004550418,0.00007170605,0.0002483565,0.0001034271,0.0001175271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003072231,0.0002182446,0.00008874689,0.0001690653,0.00001338591,0.000003933913,0.001140069,3.29538e-7,0.9822385,0.0000828162,0.00001050368,0.01296214],"study_design_scores_gemma":[0.0009100336,0.00004848472,0.114873,0.0000784954,0.00004767191,0.00002051488,0.0001025229,0.0000194738,0.8836267,0.00002176998,0.0001790879,0.00007229142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900326,0.00006409549,0.000116382,0.008216179,0.00006893988,0.001271305,0.00008918379,0.000009473198,0.0001318532],"genre_scores_gemma":[0.9985288,0.000009427624,0.0005287403,0.0006172644,0.0001393798,0.00009214829,0.00001961861,0.0000102433,0.00005441783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1147842,"threshold_uncertainty_score":0.2767825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004552871031349928,"score_gpt":0.2380350024547082,"score_spread":0.2334821314233582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}