{"id":"W2151502110","doi":"10.1124/dmd.110.034835","title":"Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Gene isoform; Biology; Alternative splicing; Glucuronidation; Biochemistry; Enzyme; Glucuronosyltransferase; HEK 293 cells; Gene; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004805328,0.0004795104,0.0004236648,0.0003077941,0.0002887504,0.0005995047,0.0003334831,0.0003330158,0.001579922],"category_scores_gemma":[0.0006177265,0.0003520061,0.0005413468,0.0002905412,0.0003250455,0.0002190612,0.0002810653,0.0009634491,0.000888165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00056859,"about_ca_system_score_gemma":0.0004866676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387737,"about_ca_topic_score_gemma":0.001631112,"domain_scores_codex":[0.9995857,0.0001534878,0.00002810395,0.00006496752,0.00009344587,0.00007430428],"domain_scores_gemma":[0.9995964,0.0001852151,0.00006183256,0.0000512763,0.00005225254,0.00005298689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002164718,0.00007573344,0.0004837315,0.00002920208,0.00001761706,0.00009733775,0.00003167915,0.0001259803,0.9968979,0.0003425803,0.0001066758,0.001574987],"study_design_scores_gemma":[0.00003790177,0.0002028903,0.003220987,0.000006722427,0.00002735422,0.000353208,0.00002305152,0.002058055,0.9911546,0.0001114849,0.002797285,0.000006298776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892377,0.003234202,0.004862784,0.0002523646,0.0001093744,0.00002512629,0.0001786807,0.00006769381,0.002032075],"genre_scores_gemma":[0.9858832,0.001612907,0.006035503,0.0001592038,0.00006516003,0.00003751551,0.001642541,0.00008347537,0.004480617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001579922,"threshold_uncertainty_score":0.005285323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004552871031349928,"score_gpt":0.2380350024547082,"score_spread":0.2334821314233582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}