{"id":"W2151521848","doi":"10.1093/hmg/ddq230","title":"Neurotoxic effects of TDP-43 overexpression in C. elegans","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research; Medical Research and Materiel Command; Centers for Disease Control and Prevention; National Institutes of Health; Michael Smith Health Research BC; ALS Association; U.S. Department of Defense","keywords":"Biology; Caenorhabditis elegans; RNA splicing; Alternative splicing; Phenotype; Cell biology; Frontotemporal lobar degeneration; Transgene; Neurotoxicity; Amyotrophic lateral sclerosis; Molecular biology; Genetics; Gene; RNA; Frontotemporal dementia; Messenger RNA; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009477503,0.0001333032,0.0002296844,0.0001393568,0.00003030755,0.00001138235,0.0001692948,0.0001469835,0.0001370187],"category_scores_gemma":[0.0001074016,0.0001183216,0.00007864762,0.0001726569,0.0001099008,0.00001859665,0.0001197559,0.0004750291,0.00001769652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002000702,"about_ca_system_score_gemma":0.000048304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003572629,"about_ca_topic_score_gemma":0.00001215126,"domain_scores_codex":[0.9987063,0.0000735605,0.0002458768,0.0002507121,0.0004288758,0.0002946334],"domain_scores_gemma":[0.9991643,0.00003126576,0.00005518957,0.000534413,0.00006688533,0.0001479252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002581582,0.0001604391,0.008106044,0.0001788531,0.000009619981,0.0001534217,0.00006808866,0.00001554904,0.9903747,0.0002390635,0.00007605715,0.0005923695],"study_design_scores_gemma":[0.00104036,0.0003091729,0.4206704,0.0001779232,0.00001055474,0.000008357225,0.000001567124,0.0001505814,0.5770601,0.0003034768,0.0001910795,0.00007645894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981323,0.0001292638,0.00008985843,0.00008204547,0.0000488227,0.0006238695,0.000001066953,0.00001889546,0.0008738943],"genre_scores_gemma":[0.998642,0.000027383,0.0008847654,0.0001656664,0.00005703238,0.00002646638,0.000007329387,0.00003918799,0.0001501672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4133146,"threshold_uncertainty_score":0.4825015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092908879952533,"score_gpt":0.3031127297648899,"score_spread":0.2921836409653646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}