{"id":"W2151521848","doi":"10.1093/hmg/ddq230","title":"Neurotoxic effects of TDP-43 overexpression in C. elegans","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research; Medical Research and Materiel Command; Centers for Disease Control and Prevention; National Institutes of Health; Michael Smith Health Research BC; ALS Association; U.S. Department of Defense","keywords":"Biology; Caenorhabditis elegans; RNA splicing; Alternative splicing; Phenotype; Cell biology; Frontotemporal lobar degeneration; Transgene; Neurotoxicity; Amyotrophic lateral sclerosis; Molecular biology; Genetics; Gene; RNA; Frontotemporal dementia; Messenger RNA; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330459,0.0006187512,0.0002529252,0.0002547435,0.0003353693,0.000248356,0.0002903598,0.0004710643,0.0008318325],"category_scores_gemma":[0.0001460825,0.0002042923,0.0003209114,0.00008681299,0.0002956396,0.0001571006,0.0002735617,0.0005528177,0.0001868659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005060433,"about_ca_system_score_gemma":0.0003982471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004283336,"about_ca_topic_score_gemma":0.007764452,"domain_scores_codex":[0.9998119,0.00001817812,0.00002984176,0.00005041163,0.00005317075,0.00003652327],"domain_scores_gemma":[0.9997377,0.00005602615,0.00006520435,0.00002574408,0.00003213947,0.00008311687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004599355,0.00002255532,0.0001197591,0.00003830442,0.000004364171,0.00006983685,0.00001180781,0.00008485599,0.9992971,0.00002547299,0.000015138,0.0002646615],"study_design_scores_gemma":[0.00001494591,0.0003738468,0.00443577,0.0000188641,0.00002518764,0.0001596856,0.00003054788,0.0009972467,0.9932822,0.000027662,0.0006245003,0.000009511941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978582,0.0004194666,0.000561034,0.00004225165,0.00002414876,0.00002963479,0.0003359376,0.00005950476,0.0006698868],"genre_scores_gemma":[0.9941916,0.0005362194,0.002360644,0.00005317749,0.00000399145,0.00006204331,0.0004054398,0.00003642993,0.002350442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004283336,"threshold_uncertainty_score":0.008516788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092908879952533,"score_gpt":0.3031127297648899,"score_spread":0.2921836409653646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}