{"id":"W2151526646","doi":"10.1111/bcpt.12267","title":"Riccardin D, a Macrocyclic Bisbibenzy, Inhibits Human Breast Cancer Growth through the Suppression of Telomerase Activity","year":2014,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China","keywords":"Telomerase; TUNEL assay; Apoptosis; Molecular biology; Cell cycle; DNA damage; Cancer cell; Annexin; Cell growth; Comet assay; Terminal deoxynucleotidyl transferase; MTT assay; Cancer research; Telomere; Chemistry; Biology; Flow cytometry; Cancer; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006576554,0.0003453903,0.0002390611,0.0003644417,0.0001048896,0.0001027052,0.0001345023,0.0001635509,0.0009065039],"category_scores_gemma":[0.00006023938,0.0000834634,0.0001558497,0.0001811794,0.00009442803,0.00009389414,0.0001167585,0.000218444,0.0002724412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000166343,"about_ca_system_score_gemma":0.0001083542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007122027,"about_ca_topic_score_gemma":0.001321491,"domain_scores_codex":[0.9999609,0.000007510191,0.000004388688,0.000008972736,0.000009680991,0.000008495086],"domain_scores_gemma":[0.9999801,0.000002798952,0.000005813602,0.000002208991,0.00000331684,0.000005699482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002083433,0.00004106064,0.0002492473,0.0001830954,0.00001375862,0.00007145577,0.000009736569,0.0001716031,0.9877595,0.0001079128,0.000203413,0.01098082],"study_design_scores_gemma":[0.000066384,0.001042547,0.006385007,0.00001601379,0.00004222373,0.0004077635,0.00001290256,0.0006018549,0.9758953,0.00003438515,0.01548704,0.00000851421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335501,0.05008181,0.003811717,0.0002256913,0.000121681,0.0001273468,0.001288692,0.0003101614,0.01048285],"genre_scores_gemma":[0.9793729,0.01352775,0.001919421,0.0001296021,0.00002401288,0.00005618248,0.001150265,0.00001790022,0.003801849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009065039,"threshold_uncertainty_score":0.003032565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02763037376310176,"score_gpt":0.3754033027164612,"score_spread":0.3477729289533594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}