{"id":"W2151526646","doi":"10.1111/bcpt.12267","title":"Riccardin D, a Macrocyclic Bisbibenzy, Inhibits Human Breast Cancer Growth through the Suppression of Telomerase Activity","year":2014,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China","keywords":"Telomerase; TUNEL assay; Apoptosis; Molecular biology; Cell cycle; DNA damage; Cancer cell; Annexin; Cell growth; Comet assay; Terminal deoxynucleotidyl transferase; MTT assay; Cancer research; Telomere; Chemistry; Biology; Flow cytometry; Cancer; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001223366,0.0003769695,0.0007452783,0.0000657833,0.0002508089,0.00001116898,0.0007334928,0.0007803877,0.0005457591],"category_scores_gemma":[0.0002452472,0.0002860953,0.0004437122,0.0002162693,0.0009745731,0.00001664143,0.000708024,0.0006735985,0.00003448771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003898679,"about_ca_system_score_gemma":0.0001868822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001073183,"about_ca_topic_score_gemma":0.0001049931,"domain_scores_codex":[0.9954603,0.00187969,0.0008330195,0.0009447784,0.000215692,0.0006665091],"domain_scores_gemma":[0.9979293,0.0004849169,0.0005588955,0.0006200151,0.0002058918,0.000200923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006726732,0.0008185836,0.006331223,0.00003287275,0.0002958283,0.000007046383,0.00003204696,0.00002035945,0.9473931,0.0002671579,0.0397035,0.004425643],"study_design_scores_gemma":[0.003487081,0.001250253,0.03321803,0.00001769348,0.0003000976,0.0000691221,0.00001762622,0.00009078448,0.9342986,0.0008005195,0.02610134,0.0003488194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911539,0.0002001031,0.000357115,0.004097964,0.002274068,0.0006327439,0.0001001553,0.00004980675,0.001134167],"genre_scores_gemma":[0.9903799,0.0003818961,0.0001861112,0.006706459,0.001633059,0.0002186029,0.00003106899,0.0000551591,0.0004077963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02688681,"threshold_uncertainty_score":0.9999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02763037376310176,"score_gpt":0.3754033027164612,"score_spread":0.3477729289533594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}