{"id":"W2151532924","doi":"10.4049/jimmunol.1102708","title":"Autoregulation of MARCH1 Expression by Dimerization and Autoubiquitination","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; Genentech","keywords":"Ubiquitin; Chemistry; Mutant; Cell biology; Transfection; Ectopic expression; Immunoprecipitation; Ubiquitin ligase; Downregulation and upregulation; Molecular biology; Gene; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342947,0.0002408077,0.0001266857,0.0001786366,0.0001387049,0.0002975298,0.0002245026,0.0001902545,0.0008872349],"category_scores_gemma":[0.0001389605,0.0001501282,0.0002085531,0.0001311305,0.0001870304,0.0002012389,0.00023002,0.0003072558,0.0004506778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004102153,"about_ca_system_score_gemma":0.0001375373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003599629,"about_ca_topic_score_gemma":0.0004331301,"domain_scores_codex":[0.9998885,0.00001821858,0.000009389924,0.00002793823,0.00002094765,0.00003492715],"domain_scores_gemma":[0.9998703,0.00002213671,0.00004161914,0.00002458425,0.00001530096,0.00002607004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006061046,0.00001190253,0.0004175857,0.00001273051,0.000001882841,0.00003188602,0.00001065342,0.00006394132,0.9983338,0.00009980393,0.00002608813,0.0009290834],"study_design_scores_gemma":[0.000007551385,0.00006306624,0.006748846,0.000002624369,0.000006724526,0.0001856893,0.00002017233,0.001956342,0.9894114,0.00007476499,0.001519397,0.000003439084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959358,0.0008340266,0.002380049,0.00005558515,0.000009658597,0.00000872203,0.0001532934,0.00006000006,0.0005629127],"genre_scores_gemma":[0.9972057,0.0002608775,0.001059982,0.00001577947,0.000004893353,0.000009744671,0.0002856275,0.000009795058,0.001147677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008872349,"threshold_uncertainty_score":0.002976298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00859384992848982,"score_gpt":0.2353168615298917,"score_spread":0.2267230116014019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}