{"id":"W2151554822","doi":"10.1038/mtna.2011.3","title":"Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells","year":2012,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Alnylam Pharmaceuticals","keywords":"Gene silencing; RNA interference; Small interfering RNA; Immune system; Myeloid; Biology; Cancer research; In vivo; Inflammation; Immunology; Medicine; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006729637,0.0005404516,0.0003035864,0.0003703168,0.0002809217,0.0003563214,0.0004295826,0.0003384787,0.001619906],"category_scores_gemma":[0.0001881197,0.0001975842,0.0003127854,0.0001500094,0.0005214506,0.0002443691,0.000243765,0.0006104652,0.0005694135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003704706,"about_ca_system_score_gemma":0.0005191203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009465376,"about_ca_topic_score_gemma":0.002035354,"domain_scores_codex":[0.9996722,0.00007544408,0.00002587674,0.00009665573,0.00008752118,0.0000423589],"domain_scores_gemma":[0.9998945,0.00001576762,0.00004115696,0.00002243471,0.00001219291,0.00001395862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004963105,0.00003079502,0.00004564567,0.00004375132,0.000004995039,0.00004968072,0.00003625037,0.00007684141,0.9970779,0.000315734,0.00005897931,0.002209791],"study_design_scores_gemma":[0.00002210724,0.0005212837,0.0003371577,0.000009531412,0.00001887281,0.0003070594,0.00001955855,0.0003900529,0.9916147,0.00008670422,0.006668229,0.000004762683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8837698,0.01014735,0.09240753,0.0005524026,0.0001488534,0.001112391,0.00102985,0.001070415,0.009761586],"genre_scores_gemma":[0.9189038,0.007309832,0.05910088,0.0002089209,0.00004527264,0.0009887476,0.001249951,0.0001793803,0.01201325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619906,"threshold_uncertainty_score":0.005419135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008436009563338067,"score_gpt":0.230263646341498,"score_spread":0.2218276367781599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}