{"id":"W2151589569","doi":"10.1093/cvr/cvn210","title":"Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel","year":2008,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health","keywords":"Diazoxide; Sulfonylurea receptor; Cromakalim; Potassium channel; Myocyte; Internal medicine; Potassium channel opener; Patch clamp; Chemistry; Endocrinology; Inward-rectifier potassium ion channel; Membrane potential; Receptor; Biophysics; Biology; Ion channel; Biochemistry; Glibenclamide; Medicine; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001569837,0.0002277264,0.0008605139,0.0004768992,0.0004232113,0.00001833287,0.00005825491,0.0002739905,0.00001182354],"category_scores_gemma":[0.0004172577,0.0001988197,0.001262457,0.0005894991,0.0006155238,0.00009485407,0.0001865634,0.0007819962,0.00006046042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002238823,"about_ca_system_score_gemma":0.0002041693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003136201,"about_ca_topic_score_gemma":0.000001398548,"domain_scores_codex":[0.9964578,0.0004663698,0.0002893058,0.0006092675,0.001643032,0.0005342567],"domain_scores_gemma":[0.9976844,0.0002374481,0.00004439434,0.0009639911,0.000746468,0.0003233548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006797614,0.0002811902,0.0009222886,0.0003625205,0.002404507,0.001191141,0.001964122,0.00007898644,0.9851621,0.0001108858,0.004048083,0.002794393],"study_design_scores_gemma":[0.001849525,0.0004729431,0.01444249,0.0003065865,0.0003833451,0.0008216618,0.001207645,0.0000482172,0.9674517,0.00001178286,0.01272578,0.0002782962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881849,0.00298051,0.00008357776,0.0004079828,0.0001954471,0.0008868,0.00005794593,0.00006435034,0.007138539],"genre_scores_gemma":[0.9934492,0.004386944,0.00006070246,0.00004380831,0.0005067847,0.00007658932,0.00007817539,0.00005861347,0.001339217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0177104,"threshold_uncertainty_score":0.8107634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0648529487173121,"score_gpt":0.3167980183218684,"score_spread":0.2519450696045563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}