{"id":"W2151590183","doi":"10.1176/appi.ajp.2009.09020186","title":"Combination of Antidepressant Medications From Treatment Initiation for Major Depressive Disorder: A Double-Blind Randomized Study","year":2009,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":315,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Mirtazapine; Venlafaxine; Bupropion; Fluoxetine; Discontinuation; Antidepressant; Major depressive disorder; Paroxetine; Sertraline; Internal medicine; Combination therapy; Medicine; Psychology; Hamilton Rating Scale for Depression; Randomized controlled trial; Psychiatry; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003561132,0.0002188031,0.001133468,0.0003433225,0.00009357199,0.00001546689,0.0001426106,0.00005211836,0.00003432033],"category_scores_gemma":[0.0001079117,0.0001503612,0.0004063161,0.0002593902,0.0001489165,0.0001661091,0.00001041093,0.0001300809,0.000001485904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000810477,"about_ca_system_score_gemma":0.0003005638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002291258,"about_ca_topic_score_gemma":0.00005350022,"domain_scores_codex":[0.9978501,0.0002097454,0.001041661,0.0002289943,0.0005044488,0.0001651068],"domain_scores_gemma":[0.9967512,0.0004145655,0.001968913,0.0003335575,0.0003744174,0.0001573483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.452153,0.02091188,0.4489156,0.0000284091,0.003583353,0.00001996042,0.002793849,0.00006931605,0.0008197756,0.0006662279,0.0004197083,0.06961896],"study_design_scores_gemma":[0.7062424,0.01228689,0.2701783,0.0002949605,0.004570592,0.00004309872,0.002267063,0.0001120587,0.0008181939,0.002991168,0.00004247326,0.0001527596],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981427,0.001722684,0.007709266,0.006242185,0.0003894564,0.002282073,0.00002829978,0.00002062379,0.0001784608],"genre_scores_gemma":[0.9870729,0.0002663507,0.01208599,0.0001221096,0.0002470195,0.00008999192,0.00007181855,0.00002133726,0.00002252367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2540894,"threshold_uncertainty_score":0.6131551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01787961112102308,"score_gpt":0.3340636851321617,"score_spread":0.3161840740111386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}