{"id":"W2151613376","doi":"10.1186/1475-2867-10-32","title":"Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination","year":2010,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Prostate Cancer Fight Foundation","keywords":"Cisplatin; Histone deacetylase inhibitor; Histone deacetylase; Cytotoxicity; ATF4; MTT assay; Viability assay; Cancer research; Activating transcription factor; ATF3; Chromatin immunoprecipitation; Apoptosis; Chemistry; Biology; Cell biology; Molecular biology; Histone; Unfolded protein response; Gene expression; Biochemistry; In vitro; Promoter; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002283843,0.0001150717,0.0001045714,0.0000515167,0.00005805875,0.00001742745,0.0002367367,0.0001197908,0.00008778149],"category_scores_gemma":[0.00009765847,0.00008847551,0.0000508041,0.00010288,0.0001506859,0.0000182806,0.00007438174,0.0003046242,9.030901e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303928,"about_ca_system_score_gemma":0.0001118885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004101037,"about_ca_topic_score_gemma":0.003524154,"domain_scores_codex":[0.9989803,0.00008477877,0.0002831676,0.0002524845,0.0002450095,0.0001542117],"domain_scores_gemma":[0.999493,0.00004002215,0.000147918,0.0001755596,0.0001112498,0.00003223457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007716524,0.0001106462,0.001462206,0.00002105611,0.000004687505,4.074507e-7,0.0004546332,0.00008898931,0.996909,0.00002317941,0.0001956512,0.0006523797],"study_design_scores_gemma":[0.0009257418,0.00003755041,0.01595576,0.00003823422,0.000002043986,0.000001224765,0.0001067328,0.0005532763,0.9814686,0.00002213108,0.0007970085,0.00009175023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978156,0.0001979717,0.0000533224,0.0003373694,0.0004721388,0.0002881587,0.00004173752,0.000003527528,0.0007901574],"genre_scores_gemma":[0.9987732,0.0000859278,0.0000579761,0.00004356619,0.0001549631,0.00007275087,0.00002898538,0.00001442958,0.0007681607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01544046,"threshold_uncertainty_score":0.3607926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009684056325507931,"score_gpt":0.2740277748789932,"score_spread":0.2643437185534853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}