{"id":"W2151613376","doi":"10.1186/1475-2867-10-32","title":"Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination","year":2010,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Prostate Cancer Fight Foundation","keywords":"Cisplatin; Histone deacetylase inhibitor; Histone deacetylase; Cytotoxicity; ATF4; MTT assay; Viability assay; Cancer research; Activating transcription factor; ATF3; Chromatin immunoprecipitation; Apoptosis; Chemistry; Biology; Cell biology; Molecular biology; Histone; Unfolded protein response; Gene expression; Biochemistry; In vitro; Promoter; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183996,0.0004246554,0.0002821136,0.0002552382,0.0001374397,0.0001695785,0.0002308113,0.000254821,0.002204991],"category_scores_gemma":[0.0001489526,0.0001074042,0.000447652,0.0002022594,0.0002225634,0.0002017411,0.000191219,0.0005040807,0.0003593839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000365319,"about_ca_system_score_gemma":0.0002660123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004308708,"about_ca_topic_score_gemma":0.0006154082,"domain_scores_codex":[0.9998919,0.00001899593,0.0000107907,0.0000200155,0.00003411297,0.00002421455],"domain_scores_gemma":[0.9999125,0.00001760582,0.00003240064,0.0000111294,0.00001037436,0.00001593208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000303998,0.0000543896,0.0004102664,0.00004302006,0.000009479905,0.00005872921,0.000006825327,0.0001208517,0.9968887,0.00004845314,0.00007801383,0.001977246],"study_design_scores_gemma":[0.00002694021,0.0004990864,0.004927895,0.000005758334,0.00003121485,0.0004575303,0.0000178985,0.0008368542,0.991275,0.00005394851,0.001863635,0.000004275539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891911,0.002539532,0.005464052,0.0002172919,0.00006223832,0.00007064009,0.0008747468,0.0001573452,0.001423094],"genre_scores_gemma":[0.9954115,0.0008675043,0.002108002,0.00004541523,0.00001155922,0.00004132045,0.0005802601,0.000014972,0.0009195712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002204991,"threshold_uncertainty_score":0.007376432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009684056325507931,"score_gpt":0.2740277748789932,"score_spread":0.2643437185534853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}