{"id":"W2151625463","doi":"10.1152/physrev.00035.2005","title":"Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins","year":2006,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":749,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"ATP-binding cassette transporter; Multidrug Resistance-Associated Proteins; Biochemistry; Cystic fibrosis transmembrane conductance regulator; Multiple drug resistance; Cyclic nucleotide-binding domain; Chemistry; ABCC1; Transporter; Xenobiotic; Efflux; Biology; Nucleotide; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002313032,0.0002462552,0.0003525462,0.0002792314,0.0002427926,0.0008589751,0.0001781819,0.0006794934,0.001425603],"category_scores_gemma":[0.0002382755,0.0001623113,0.0003556634,0.0003643527,0.0002227411,0.0006740148,0.0003883837,0.0004122546,0.001576351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000518913,"about_ca_system_score_gemma":0.0002657041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004685152,"about_ca_topic_score_gemma":0.000392539,"domain_scores_codex":[0.9996166,0.00008088719,0.00003760177,0.00007472065,0.0001327624,0.00005733245],"domain_scores_gemma":[0.9998671,0.00001157099,0.0000368679,0.0000149501,0.00004800375,0.00002152847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001405076,0.00002486544,0.001041621,0.0001995788,0.00003589489,0.0005357407,0.00007302869,0.0002483853,0.9694774,0.003818074,0.001713113,0.02269166],"study_design_scores_gemma":[0.0000722045,0.0005495175,0.01863004,0.00008723773,0.00009435635,0.004356389,0.0002509435,0.008208082,0.7530527,0.002051317,0.21259,0.00005736553],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8069755,0.09978798,0.06400327,0.003168698,0.00053971,0.000109865,0.001696738,0.001292124,0.02242609],"genre_scores_gemma":[0.9539614,0.02001719,0.01191992,0.0005343815,0.00009767923,0.00006677472,0.00139134,0.00006609598,0.01194518],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001425603,"threshold_uncertainty_score":0.004769087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06526116352986933,"score_gpt":0.3273207278770836,"score_spread":0.2620595643472143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}