{"id":"W2151645052","doi":"10.1038/ng.2754","title":"A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia","year":2013,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Health and Medical Research Council; KWF Kankerbestrijding; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Geoffrey Beene Cancer Research Center; American Lebanese Syrian Associated Charities; National Institute of General Medical Sciences; Medical Research Council; Deutsche Forschungsgemeinschaft; St. Jude Children's Research Hospital","keywords":"Biology; PAX5; Loss of heterozygosity; Germline; Germline mutation; Genetics; Mutation; Allele; Molecular biology; B cell; Somatic cell; Cancer research; Gene; Transcription factor; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585683,0.000363075,0.0002342689,0.0009380534,0.0003964686,0.0003214059,0.0003568197,0.0006168952,0.005443414],"category_scores_gemma":[0.0005433119,0.0001965673,0.0003174422,0.0005840623,0.0003871001,0.0001539892,0.0004246631,0.0004321962,0.0004621531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002701145,"about_ca_system_score_gemma":0.0002006161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001122616,"about_ca_topic_score_gemma":0.001186905,"domain_scores_codex":[0.9997746,0.00005380391,0.00002598467,0.00004003702,0.00005141168,0.00005422802],"domain_scores_gemma":[0.9996293,0.0001432389,0.0000836812,0.00003400661,0.00001316067,0.00009677055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001711117,0.0002949802,0.1114506,0.00007676466,0.0001371522,0.08302622,0.0006173264,0.000693759,0.7867314,0.002341092,0.0006721662,0.01224751],"study_design_scores_gemma":[0.0002661125,0.002162592,0.5585667,0.00005588021,0.000364177,0.3183304,0.001009947,0.004148955,0.1054642,0.001564408,0.007982805,0.00008376086],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983801,0.00006542404,0.0002291722,0.00006305921,0.000007673157,0.000006648338,0.00008439479,0.00002777185,0.001135808],"genre_scores_gemma":[0.9995,0.00002767309,0.0001282826,0.00001680124,0.000006344364,0.000001784033,0.00005147978,0.000006539623,0.0002610273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005443414,"threshold_uncertainty_score":0.01821005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009473553381522998,"score_gpt":0.2931197454918782,"score_spread":0.2836461921103552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}