{"id":"W2151685818","doi":"10.1016/j.neuropharm.2015.05.033","title":"The highly-selective 5-HT1A agonist F15599 reduces l-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque","year":2015,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Krembil Foundation; National Institutes of Health; Parkinson Society Canada; Edmond J. Safra Philanthropic Foundation; Health Canada","keywords":"Dyskinesia; Agonist; Parkinsonism; MPTP; Pharmacology; Parkinson's disease; Medicine; Levodopa; Stimulation; Psychology; Receptor; Internal medicine; Anesthesia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004153492,0.0004074613,0.0005381984,0.0001743092,0.0005300412,0.00008997497,0.000438107,0.0001219586,0.00001924434],"category_scores_gemma":[0.0001524008,0.0002473698,0.0001272441,0.0005747021,0.0001707572,0.0001045987,0.000104936,0.0005857823,0.0000975536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025532,"about_ca_system_score_gemma":0.0004096279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000134463,"about_ca_topic_score_gemma":0.00004480415,"domain_scores_codex":[0.9969144,0.0007645074,0.0004383376,0.0006863353,0.0004834954,0.0007128879],"domain_scores_gemma":[0.998466,0.0003327431,0.0002269258,0.0004246149,0.0002098884,0.0003398317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01217591,0.005063313,0.08582474,0.000108027,0.0009683307,0.01221204,0.003332478,0.0003044581,0.8353817,0.001866397,0.009036077,0.03372655],"study_design_scores_gemma":[0.02523134,0.003476502,0.7353508,0.0001522572,0.001155594,0.001820588,0.00072254,0.002473857,0.1886422,0.0005033836,0.03964906,0.0008218325],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989525,0.000709555,0.000003702702,0.005499434,0.001071143,0.001294305,0.0000170021,0.0001056983,0.001774113],"genre_scores_gemma":[0.9962583,0.0003376742,0.00009813103,0.002576494,0.000370382,0.0001261886,0.00002029534,0.00006508882,0.0001474997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6495261,"threshold_uncertainty_score":0.9999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04706754243601451,"score_gpt":0.3214677783971509,"score_spread":0.2744002359611364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}