{"id":"W2151698969","doi":"10.1158/1078-0432.ccr-04-2140","title":"Timing Is Everything: Preclinical Evidence Supporting Simultaneous Rather Than Sequential Chemohormonal Therapy for Prostate Cancer","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; BC Cancer Agency","funders":"","keywords":"Paclitaxel; LNCaP; Prostate cancer; Medicine; Internal medicine; Oncology; Chemotherapy; Androgen; Cancer; Castration; Endocrinology; Cancer research; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007394899,0.0003795335,0.0008784138,0.000205712,0.0005383511,0.0001730629,0.0005465627,0.0004378914,0.002433721],"category_scores_gemma":[0.00355172,0.0002812431,0.0005978939,0.0005868196,0.0009474891,0.0003409648,0.0002911668,0.001961128,0.000124088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008355611,"about_ca_system_score_gemma":0.003862416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006242441,"about_ca_topic_score_gemma":0.0001832198,"domain_scores_codex":[0.9930639,0.0004890963,0.001430722,0.001391911,0.001841261,0.00178315],"domain_scores_gemma":[0.9910451,0.005421209,0.0002703608,0.0007224277,0.001714568,0.0008263299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0339371,0.001438801,0.1548983,0.0005204335,0.0009226933,0.0001936435,0.002355195,0.0001445621,0.01105995,0.00002123248,0.03709826,0.7574099],"study_design_scores_gemma":[0.04850262,0.01554975,0.03579328,0.005658181,0.0006246499,0.0000878979,0.001045604,0.05649453,0.1503223,0.001258632,0.6824293,0.002233332],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9187248,0.02390848,0.00006441808,0.05149781,0.000483199,0.004605832,0.0001563316,0.0001307656,0.0004284024],"genre_scores_gemma":[0.9287167,0.03614018,0.0009367894,0.002126861,0.004514323,0.001968274,0.00004228715,0.0001302622,0.02542438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7551765,"threshold_uncertainty_score":0.999964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4639134953629581,"score_gpt":0.6067462781873147,"score_spread":0.1428327828243567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}