{"id":"W2151700792","doi":"10.1016/j.bbamcr.2008.05.022","title":"Cytosolic prion protein is the predominant anti-Bax prion protein form: Exclusion of transmembrane and secreted prion protein forms in the anti-Bax function","year":2008,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Fonds de Recherche du Québec - Santé; University of Washington","keywords":"Cytosol; Transmembrane protein; Cell biology; Mutant; Biology; Subcellular localization; Transmembrane domain; Chemistry; Molecular biology; Biochemistry; Membrane; Gene; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002735414,0.0003893753,0.0003359419,0.0002707075,0.0002764972,0.0005091703,0.00020645,0.0003025027,0.001411023],"category_scores_gemma":[0.0002497194,0.0001447062,0.0002019443,0.0002063428,0.0002872482,0.0003966826,0.0002391283,0.0004759407,0.00087827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634504,"about_ca_system_score_gemma":0.0002134428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142947,"about_ca_topic_score_gemma":0.0002060842,"domain_scores_codex":[0.9998374,0.00002765908,0.00001961904,0.00003797379,0.00004270197,0.00003456123],"domain_scores_gemma":[0.9996452,0.00004339534,0.00007211731,0.00003031957,0.00008533831,0.0001235993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002591537,0.00001367365,0.000877726,0.00003152394,0.000003360717,0.0001740478,0.00001930386,0.00001128608,0.9973457,0.0001733222,0.00003262963,0.001058234],"study_design_scores_gemma":[0.00003639241,0.0003205281,0.02290524,0.000009014439,0.00003547122,0.006390817,0.00008234785,0.0009082,0.9664432,0.0004183968,0.002441484,0.000008860881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947945,0.001380826,0.002830772,0.00009013862,0.00001806286,0.000006916102,0.0001387582,0.00004649227,0.0006934926],"genre_scores_gemma":[0.9959324,0.0005032103,0.001675515,0.00004321965,0.00002411788,0.000006298514,0.0004759544,0.00001977762,0.001319486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411023,"threshold_uncertainty_score":0.00472033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02244644487055578,"score_gpt":0.2833009136259593,"score_spread":0.2608544687554035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}