{"id":"W2151701983","doi":"10.1158/1535-7163.mct-09-0962","title":"SKI-606 (Bosutinib) Blocks Prostate Cancer Invasion, Growth, and Metastasis In vitro and In vivo through Regulation of Genes Involved in Cancer Growth and Skeletal Metastasis","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Bosutinib; Cancer; Metastasis; Cancer research; Prostate cancer; Matrigel; Bone metastasis; Cancer cell; Medicine; Biology; Pathology; Internal medicine; Angiogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284422,0.0005608014,0.0003773912,0.0002711887,0.0001414291,0.0002681505,0.0002067213,0.0001547063,0.001357056],"category_scores_gemma":[0.00006110527,0.000110238,0.0003157459,0.000218469,0.0002048658,0.0001306812,0.0000818948,0.0006880643,0.0004519495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577124,"about_ca_system_score_gemma":0.000331815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009774729,"about_ca_topic_score_gemma":0.002574106,"domain_scores_codex":[0.9999118,0.00001254552,0.000007717566,0.00001087246,0.00002445034,0.00003265569],"domain_scores_gemma":[0.9999582,0.000004677651,0.00001446094,0.000002866506,0.000005337777,0.00001450275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002548597,0.0001950895,0.0002894507,0.0001995162,0.00001779408,0.00004585959,0.000008482451,0.0001949758,0.9937938,0.00006939624,0.0002230881,0.004707669],"study_design_scores_gemma":[0.0001172799,0.002652711,0.006685009,0.00001198888,0.00007352423,0.0003702129,0.00002316578,0.0007979355,0.9851391,0.00003399555,0.004087214,0.000007853189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752526,0.01682911,0.001889769,0.0003381083,0.0001274166,0.00006500647,0.0009297049,0.0002213003,0.004346887],"genre_scores_gemma":[0.9853967,0.009186364,0.00122677,0.000108277,0.00004197663,0.00005414739,0.0014488,0.00002420081,0.002512794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357056,"threshold_uncertainty_score":0.004539788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02005331801965799,"score_gpt":0.2831139252558011,"score_spread":0.2630606072361432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}