{"id":"W2151701983","doi":"10.1158/1535-7163.mct-09-0962","title":"SKI-606 (Bosutinib) Blocks Prostate Cancer Invasion, Growth, and Metastasis In vitro and In vivo through Regulation of Genes Involved in Cancer Growth and Skeletal Metastasis","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Bosutinib; Cancer; Metastasis; Cancer research; Prostate cancer; Matrigel; Bone metastasis; Cancer cell; Medicine; Biology; Pathology; Internal medicine; Angiogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002666131,0.0004608046,0.0008462255,0.0002825145,0.00005783378,0.00003533114,0.0001118171,0.0002356497,0.00004616589],"category_scores_gemma":[0.00002700985,0.0004184286,0.00008357917,0.0006581047,0.0003478553,0.0002022068,0.0001130224,0.0004570062,1.738005e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000295685,"about_ca_system_score_gemma":0.0005008776,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01286447,"about_ca_topic_score_gemma":0.01031873,"domain_scores_codex":[0.9975034,0.0001443801,0.0006702575,0.0007376818,0.0004201403,0.0005241115],"domain_scores_gemma":[0.9990296,0.00008842342,0.0002623673,0.000361,0.0001235605,0.0001349862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006080577,0.0001922865,0.1560387,0.0004562883,0.000373522,0.00005876426,0.001493987,0.00004205744,0.8219601,0.00008714241,0.000009346357,0.01867973],"study_design_scores_gemma":[0.009359869,0.0001406539,0.03047893,0.0003556073,0.0007262586,0.00002700549,0.0002029025,0.0005294294,0.9560104,0.0006738735,0.00106781,0.0004272419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548047,0.04197599,0.00002671456,0.001664049,0.0001431155,0.001097797,0.0001900093,0.00002218892,0.00007542975],"genre_scores_gemma":[0.9642172,0.03218697,0.001827124,0.001187475,0.00004923339,0.0003970707,0.00002692737,0.00007784969,0.00003007882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1340503,"threshold_uncertainty_score":0.9998267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02005331801965799,"score_gpt":0.2831139252558011,"score_spread":0.2630606072361432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}