{"id":"W2151731359","doi":"10.1016/j.bpj.2009.12.1354","title":"Structural and Functional Characterization of an Unusual SH3 Domain from the Fungal Adaptor Protein Bem1","year":2010,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Fungal Biology and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"SH3 domain; Signal transducing adaptor protein; GTPase; WW domain; Biology; Cyclic nucleotide-binding domain; SH2 domain; Binding domain; Cell biology; Chemistry; Computational biology; Biochemistry; Biophysics; Peptide sequence; Binding site; Signal transduction; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751442,0.0002157924,0.0002092946,0.0001516266,0.0002987549,0.000294253,0.0003126429,0.0003934679,0.0006969327],"category_scores_gemma":[0.0002300639,0.0001062541,0.0002538525,0.0001860799,0.0002068601,0.0002216798,0.0002317631,0.0006000032,0.0003158452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005290827,"about_ca_system_score_gemma":0.0002195829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154508,"about_ca_topic_score_gemma":0.001179263,"domain_scores_codex":[0.9999398,0.000008138352,0.000005383325,0.00001232238,0.00001988169,0.00001443454],"domain_scores_gemma":[0.9999093,0.00001763111,0.00002214995,0.00000884305,0.00001603237,0.00002597749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002439315,0.00003800144,0.0008139743,0.00004573159,0.000008380456,0.0002828524,0.00004834934,0.0002492323,0.9963422,0.0003194193,0.0001212319,0.001486505],"study_design_scores_gemma":[0.00004320878,0.0001225048,0.02005911,0.00001349319,0.00003774268,0.001829705,0.0001514548,0.004515599,0.9649835,0.0002581614,0.007965241,0.00002029485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972006,0.0005790771,0.001411419,0.0001253286,0.00001548904,0.00001034417,0.0002190313,0.00001329857,0.0004254995],"genre_scores_gemma":[0.9954156,0.0002722081,0.001878616,0.00006731426,0.000006941234,0.000009993223,0.001162735,0.00001005162,0.001176656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154508,"threshold_uncertainty_score":0.003838778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198357363458853,"score_gpt":0.2408284032539862,"score_spread":0.2288448296193977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}