{"id":"W2151768713","doi":"10.1128/aac.02403-13","title":"<i>In Vitro</i>Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Reverse transcriptase; Efavirenz; Rilpivirine; Virology; Reverse-transcriptase inhibitor; Etravirine; Mutant; In vitro; Potency; IC50; Chemistry; Virus; Biology; Polymerase chain reaction; Viral load; Antiretroviral therapy; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003555242,0.0005361297,0.0004264082,0.0002141234,0.0002042766,0.0003045578,0.0003658986,0.0002407567,0.001092384],"category_scores_gemma":[0.0003074604,0.0001523687,0.0004714532,0.000299716,0.0001282884,0.0001780907,0.0001363359,0.000457703,0.0007813199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003569653,"about_ca_system_score_gemma":0.0002514748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001675127,"about_ca_topic_score_gemma":0.002075737,"domain_scores_codex":[0.9996986,0.00008749212,0.00003395294,0.0000427599,0.00009803905,0.00003911588],"domain_scores_gemma":[0.9998322,0.00003937251,0.00003335904,0.00001965006,0.00005601579,0.000019395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001861628,0.0001158843,0.0004019058,0.0001349774,0.00001627147,0.00005861471,0.00001608258,0.0009043665,0.9953068,0.0001185899,0.0002358041,0.002504577],"study_design_scores_gemma":[0.00001301498,0.0009155156,0.002027352,0.000009200354,0.00002922481,0.0002414119,0.00001125974,0.002123086,0.9906476,0.00003975677,0.003933388,0.000009145695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960878,0.01220288,0.01225677,0.0002448169,0.0001390208,0.0001988816,0.006727045,0.0001632343,0.00718931],"genre_scores_gemma":[0.9614328,0.006019462,0.01456841,0.0002292498,0.00006696869,0.0001771951,0.01374475,0.00006198472,0.003699255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001675127,"threshold_uncertainty_score":0.003654361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008411565222724697,"score_gpt":0.2200918845106389,"score_spread":0.2116803192879142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}