{"id":"W2151768713","doi":"10.1128/aac.02403-13","title":"<i>In Vitro</i>Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Reverse transcriptase; Efavirenz; Rilpivirine; Virology; Reverse-transcriptase inhibitor; Etravirine; Mutant; In vitro; Potency; IC50; Chemistry; Virus; Biology; Polymerase chain reaction; Viral load; Antiretroviral therapy; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005013065,0.0001786254,0.0003187399,0.0001409978,0.00003688083,0.00001935614,0.00004448611,0.00008139091,0.0005602225],"category_scores_gemma":[0.000002610041,0.0001503477,0.00007646844,0.0001778077,0.00005412154,0.0001763745,0.00001104439,0.00007409475,0.00005471795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002866078,"about_ca_system_score_gemma":0.00003371102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005737661,"about_ca_topic_score_gemma":0.000001477246,"domain_scores_codex":[0.999128,0.00001146875,0.0003116578,0.0002361487,0.0001094883,0.0002032015],"domain_scores_gemma":[0.9996602,0.000006544536,0.00008227876,0.0001302182,0.00004937074,0.0000713804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000252336,0.0006578334,0.007398843,0.00007490532,0.00007133847,0.00001284154,0.001051168,7.416923e-8,0.9642523,0.000008812575,0.02438743,0.001832125],"study_design_scores_gemma":[0.008620543,0.0000626175,0.03569442,0.0002062853,0.00005714286,0.00003010088,0.00006029794,0.00006989561,0.8767496,0.000008542508,0.07821271,0.0002278042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838257,0.00000650868,0.0001193576,0.01509734,0.00009280064,0.0005649035,0.0000568012,0.00001800086,0.0002185978],"genre_scores_gemma":[0.9765911,0.0004162765,0.002262181,0.01030912,0.00008617515,0.00001880172,0.000231276,0.00003468226,0.01005036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08750265,"threshold_uncertainty_score":0.6134043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008411565222724697,"score_gpt":0.2200918845106389,"score_spread":0.2116803192879142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}