{"id":"W2151795220","doi":"10.1042/bst0351027","title":"Structure-based optimization of PKCθ inhibitors","year":2007,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Protein kinase C; Chemistry; Pharmacology; Computational biology; Cell biology; Computer science; Biochemistry; Biology; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002656448,0.001076631,0.001228638,0.001124762,0.0002449434,0.0006631223,0.0009850439,0.0006818813,0.002277518],"category_scores_gemma":[0.0002274184,0.0003612978,0.0004730312,0.001087375,0.0002459949,0.0006863278,0.0004029518,0.001003905,0.002058178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008825467,"about_ca_system_score_gemma":0.0004570392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008370712,"about_ca_topic_score_gemma":0.001638195,"domain_scores_codex":[0.9998381,0.00002611857,0.00001369133,0.0000296096,0.00006965384,0.00002277134],"domain_scores_gemma":[0.9999516,0.000008112938,0.00001236542,0.000003420484,0.0000184678,0.000005946203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003925313,0.0004240785,0.0002183879,0.007564976,0.0001226556,0.0009532182,0.00009246483,0.02366119,0.1098282,0.01597521,0.01773454,0.8230326],"study_design_scores_gemma":[0.0004521938,0.00138984,0.0009784307,0.0009221235,0.0001941879,0.002451874,0.00007473572,0.007955736,0.1335354,0.005821884,0.8461419,0.00008177735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02227063,0.9361562,0.01580664,0.0009421923,0.0005477289,0.0002358538,0.0004209196,0.0002774704,0.02334248],"genre_scores_gemma":[0.06481653,0.9003143,0.01758921,0.0005500878,0.0001736406,0.000195656,0.0007437919,0.00004985306,0.015567],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002277518,"threshold_uncertainty_score":0.007619083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02298060238053531,"score_gpt":0.2959054845597473,"score_spread":0.272924882179212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}