{"id":"W2151805116","doi":"10.1128/jvi.00927-07","title":"Human Immunodeficiency Virus Type 1 gp41 Antibodies That Mask Membrane Proximal Region Epitopes: Antibody Binding Kinetics, Induction, and Potential for Regulation in Acute Infection","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; York University; Center for AIDS Research, University of Washington; Bill and Melinda Gates Foundation","keywords":"Gp41; Epitope; Monoclonal antibody; Antibody; Biology; Virology; Antigen; Molecular biology; Viral envelope; Virus; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006342153,0.0001322402,0.0002971623,0.0005556304,0.0001943241,0.00001675088,0.00007892538,0.0002644696,0.00003383855],"category_scores_gemma":[0.0000645995,0.0001082344,0.00007115352,0.0001408097,0.000213552,0.0001987251,0.00003690378,0.0003112817,0.0000126231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007733562,"about_ca_system_score_gemma":0.00003453992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007342634,"about_ca_topic_score_gemma":0.0000548186,"domain_scores_codex":[0.9988484,0.000143203,0.0004351297,0.0001724209,0.00005514927,0.0003457443],"domain_scores_gemma":[0.999328,0.00005942799,0.0003372251,0.0001001412,0.0001489857,0.00002626623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001185419,0.0002630733,0.02487096,0.00001721898,0.0001883341,0.00005509225,0.0002422332,0.00002516348,0.9702902,0.0001245121,0.0000944998,0.002643269],"study_design_scores_gemma":[0.0041511,0.004211088,0.7100405,0.00004815538,0.0001413823,0.002209024,0.0001410963,0.000008657029,0.2768619,0.000427739,0.001608533,0.0001507904],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950647,0.001177376,0.002471534,0.0002460275,0.0007123183,0.0002639876,0.000007038377,0.00001026802,0.00004673162],"genre_scores_gemma":[0.9984958,0.0009482895,0.0001792236,0.00001715381,0.00008064261,0.000002543891,0.00007267437,0.00001152569,0.0001922151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6934283,"threshold_uncertainty_score":0.4413669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02250170485692217,"score_gpt":0.3143447937783086,"score_spread":0.2918430889213864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}