{"id":"W2151805116","doi":"10.1128/jvi.00927-07","title":"Human Immunodeficiency Virus Type 1 gp41 Antibodies That Mask Membrane Proximal Region Epitopes: Antibody Binding Kinetics, Induction, and Potential for Regulation in Acute Infection","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; York University; Center for AIDS Research, University of Washington; Bill and Melinda Gates Foundation","keywords":"Gp41; Epitope; Monoclonal antibody; Antibody; Biology; Virology; Antigen; Molecular biology; Viral envelope; Virus; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004103638,0.0003624275,0.0002814501,0.0001745269,0.0001601924,0.000394572,0.0003079576,0.0003618305,0.0008327421],"category_scores_gemma":[0.0006818944,0.0002925681,0.0001791166,0.0001377881,0.0001904288,0.0002905118,0.000148284,0.0006192033,0.000338721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004761872,"about_ca_system_score_gemma":0.0001934582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006917679,"about_ca_topic_score_gemma":0.0005679893,"domain_scores_codex":[0.999696,0.00007479482,0.00002253166,0.00004778458,0.00005438949,0.0001045841],"domain_scores_gemma":[0.9996244,0.000176231,0.000057626,0.00003951624,0.00004862004,0.00005352838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000435215,0.00009873395,0.001884449,0.00005203891,0.000006558049,0.00004898749,0.00003487801,0.0001314861,0.9932925,0.00009266947,0.00006647898,0.003855994],"study_design_scores_gemma":[0.00008503059,0.00140171,0.02958541,0.00001383247,0.00003269027,0.0005766512,0.00003396888,0.003197307,0.9637068,0.00009563657,0.001262131,0.000008794818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916542,0.002373096,0.004633694,0.00003711623,0.00001001181,0.00005396226,0.00008903747,0.00009144915,0.00105736],"genre_scores_gemma":[0.9969318,0.0004234162,0.001699058,0.00004617198,0.000009843482,0.00004498591,0.0001797011,0.000009633585,0.0006553219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008327421,"threshold_uncertainty_score":0.003454983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02250170485692217,"score_gpt":0.3143447937783086,"score_spread":0.2918430889213864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}