{"id":"W2151877403","doi":"10.1095/biolreprod.109.080887","title":"The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1","year":2010,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":444,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University; Université du Québec; Université du Québec à Montréal; Université Laval; Royal Victoria Hospital; Montreal Neurological Institute and Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"TFAM; Biology; Mitochondrial DNA; Genetics; Mitochondrial biogenesis; Oocyte; Sperm; Mitochondrion; Zygote; Somatic cell; Low copy number; Genome; Embryo; Gene; Embryogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003360104,0.00008629255,0.0001395027,0.00003012073,0.00004672425,0.000002570154,0.0001375683,0.0002604036,0.00006572089],"category_scores_gemma":[0.0004986296,0.00006636687,0.00006875755,0.00008387811,0.0003183796,0.000002573266,0.00004535215,0.0001373981,0.00001071627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003402873,"about_ca_system_score_gemma":0.00004327645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008394649,"about_ca_topic_score_gemma":0.0003360365,"domain_scores_codex":[0.9990175,0.000131736,0.000292993,0.0003695483,0.00004478867,0.0001433811],"domain_scores_gemma":[0.9991375,0.00001873862,0.0001472745,0.0005667305,0.000105279,0.00002444586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004628285,0.00004371379,0.05530946,0.000003604257,0.0000103224,1.250866e-7,0.00002606886,0.000001094607,0.9331261,0.0009614271,0.0003534655,0.009701792],"study_design_scores_gemma":[0.0002590033,0.0001417372,0.005880574,0.000001275748,0.000003924598,0.00001983144,0.00004614397,0.000001387866,0.7564662,0.001054532,0.2360733,0.00005209132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943888,0.0004392012,0.0001129725,0.0002639245,0.003111621,0.0001742096,0.000007675767,0.000005772831,0.001495793],"genre_scores_gemma":[0.9973441,0.0001033107,0.001060055,0.0000118135,0.0007889722,0.00001789348,0.0000505199,0.000007420193,0.0006158758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2357199,"threshold_uncertainty_score":0.2706362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006973504650095238,"score_gpt":0.2507418593963411,"score_spread":0.2437683547462459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}