{"id":"W2151877403","doi":"10.1095/biolreprod.109.080887","title":"The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1","year":2010,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":444,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University; Université du Québec; Université du Québec à Montréal; Université Laval; Royal Victoria Hospital; Montreal Neurological Institute and Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"TFAM; Biology; Mitochondrial DNA; Genetics; Mitochondrial biogenesis; Oocyte; Sperm; Mitochondrion; Zygote; Somatic cell; Low copy number; Genome; Embryo; Gene; Embryogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005512115,0.0004409346,0.000312287,0.0006603653,0.000285279,0.0008631377,0.0009934916,0.0006231005,0.001177845],"category_scores_gemma":[0.001154758,0.000304976,0.0001738497,0.0003126474,0.0009972616,0.000909037,0.0007173281,0.0005525855,0.0004016732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006266616,"about_ca_system_score_gemma":0.0002302023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003974928,"about_ca_topic_score_gemma":0.0003230633,"domain_scores_codex":[0.9996995,0.000058918,0.00002099552,0.00007646897,0.0001153864,0.00002877569],"domain_scores_gemma":[0.9989084,0.0004319433,0.0003742297,0.00006594986,0.00008652789,0.0001329055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003907778,0.00005702297,0.008865203,0.0002993874,0.00003397391,0.0003213639,0.0001421524,0.001162209,0.9551876,0.005468669,0.0003491002,0.02772265],"study_design_scores_gemma":[0.0001187991,0.001623011,0.2153285,0.0001533972,0.0002128847,0.005227751,0.0002278806,0.01207797,0.73166,0.01099921,0.02219566,0.0001749219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8891935,0.07430439,0.02473433,0.001075111,0.0001597055,0.00004317655,0.0008347556,0.0002715167,0.009383594],"genre_scores_gemma":[0.9839953,0.01080765,0.003126502,0.0001079038,0.0001094779,0.0000263863,0.0002536826,0.00004417711,0.001528994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177845,"threshold_uncertainty_score":0.004546821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006973504650095238,"score_gpt":0.2507418593963411,"score_spread":0.2437683547462459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}